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    POP4 RNase P/RNase MRP complex subunit [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    POP4
    Official Full Name
    RNase P/RNase MRP complex subunit
    Primary source
    SGD:S000000461
    Locus tag
    YBR257W
    See related
    AllianceGenome:SGD:S000000461; FungiDB:YBR257W; VEuPathDB:YBR257W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA primary transcript binding activity. Contributes to ribonuclease MRP activity and ribonuclease P activity. Involved in RNA metabolic process. Part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Orthologous to human POP4 (POP4 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See POP4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (728885..729724)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Rcf3p Neighboring gene riboflavin synthase Neighboring gene Shg1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and biochemical analyses of yeast RNase MRP. Tollervey D. Mol Biol Rep, 1995-1996. PMID 8901491
    2. A novel protein shared by RNase MRP and RNase P. Chu S, et al. RNA, 1997 Apr. PMID 9085845, Free PMC Article
    3. Interactions of a Pop5/Rpp1 heterodimer with the catalytic domain of RNase MRP. Perederina A, et al. RNA, 2011 Oct. PMID 21878546, Free PMC Article
    4. Conserved regions of ribonucleoprotein ribonuclease MRP are involved in interactions with its substrate. Esakova O, et al. Nucleic Acids Res, 2013 Aug. PMID 23700311, Free PMC Article
    5. Comparison of mitochondrial and nucleolar RNase MRP reveals identical RNA components with distinct enzymatic activities and protein components. Lu Q, et al. RNA, 2010 Mar. PMID 20086051, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP.
      Title: Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA primary transcript binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ribonuclease MRP activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ribonuclease P RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease P RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribonuclease P activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intronic box C/D snoRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA 5'-leader removal IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nucleolar ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease MRP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease MRP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonuclease MRP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease MRP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonuclease P complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNase P/RNase MRP complex subunit
    NP_009816.1
    • Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      728885..729724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178605.1 → NP_009816.1  TPA: RNase P/RNase MRP complex subunit [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009816.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQQ4, P38336
      UniProtKB/TrEMBL
      A6ZLJ7, B3LMQ4, B5VEK6, D3UF05, N1P8K8
      Conserved Domains (1) summary
      pfam01868
      Location:172 → 263
      UPF0086; Domain of unknown function UPF0086
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38336.1

    Gene LinkOut

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