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    DCC1 Dcc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DCC1
    Official Full Name
    Dcc1p
    Primary source
    SGD:S000000521
    Locus tag
    YCL016C
    See related
    AllianceGenome:SGD:S000000521; FungiDB:YCL016C; VEuPathDB:YCL016C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in maintenance of DNA trinucleotide repeats and mitotic sister chromatid cohesion. Acts upstream of or within telomere tethering at nuclear periphery. Part of Ctf18 RFC-like complex. Orthologous to human DSCC1 (DNA replication and sister chromatid cohesion 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DCC1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (94621..95763, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene 3-isopropylmalate dehydrogenase Neighboring gene cysteine desulfurase Neighboring gene Bud3p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mft1, identified from a genome-wide screen of the yeast haploid mutants, mediates cell cycle arrest to counteract quinoxaline-induced toxicity. Sulaiman AA, et al. Front Genet, 2023. PMID 38283148, Free PMC Article
    2. The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time. Hiraga S, et al. EMBO J, 2006 Apr 5. PMID 16525505, Free PMC Article
    3. Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II. Petronczki M, et al. J Cell Sci, 2004 Jul 15. PMID 15226378
    4. Conserved interaction of Ctf18-RFC with DNA polymerase ε is critical for maintenance of genome stability in Saccharomyces cerevisiae. Okimoto H, et al. Genes Cells, 2016 May. PMID 26987677
    5. X-ray survival characteristics and genetic analysis for nine Saccharomyces deletion mutants that show altered radiation sensitivity. Game JC, et al. Genetics, 2005 Jan. PMID 15371366, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of DNA trinucleotide repeats IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within telomere tethering at nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ctf18 RFC-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ctf18 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dcc1p
    NP_009913.2
    • Subunit of a complex with Ctf8p and Ctf18p; shares some components with Replication Factor C; required for sister chromatid cohesion and telomere length maintenance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      94621..95763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178663.1 → NP_009913.2  TPA: Dcc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009913.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQZ8, P25559, Q8NIM7
      UniProtKB/TrEMBL
      A6ZTH0, C7GQK4, C8Z471, G2WA06, N1P672
      Conserved Domains (1) summary
      pfam09724
      Location:15 → 348
      Dcc1; Sister chromatid cohesion protein Dcc1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25559.2

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