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    MGT1 methylated-DNA--protein-cysteine methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MGT1
    Official Full Name
    methylated-DNA--protein-cysteine methyltransferase
    Primary source
    SGD:S000002359
    Locus tag
    YDL200C
    See related
    AllianceGenome:SGD:S000002359; FungiDB:YDL200C; VEuPathDB:YDL200C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in DNA alkylation repair. Located in peroxisome. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MGT1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (100501..101067, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL11 Neighboring gene tRNA (guanine46-N7)-methyltransferase Neighboring gene uncharacterized protein Neighboring gene Ggc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of how proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase
      Title: Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA alkylation repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome HDA PubMed 

    General protein information

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    Preferred Names
    methylated-DNA--protein-cysteine methyltransferase
    NP_010081.2
    • DNA repair methyltransferase (6-O-methylguanine-DNA methylase); involved in protection against DNA alkylation damage; localizes to the peroxisome in a Pex5p-dependent manner

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      100501..101067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180260.1 → NP_010081.2  TPA: methylated-DNA--protein-cysteine methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010081.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZXD3, D6VRF4, P26188
      UniProtKB/TrEMBL
      B5VF77, C7GV61, C8Z6A5, G2WBW7, N1PAF9
      Conserved Domains (1) summary
      COG0350
      Location:5 → 179
      AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26188.3

    Gene LinkOut

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