CCC2 Cu(2+)-transporting P-type ATPase CCC2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CCC2
Official Full Name: Cu(2+)-transporting P-type ATPase CCC2
Primary source: SGD:S000002678
Locus tag: YDR270W
See related: AllianceGenome:SGD:S000002678; FungiDB:YDR270W; VEuPathDB:YDR270W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ATPase-coupled monoatomic cation transmembrane transporter activity and copper ion binding activity. Involved in copper ion export and intracellular iron ion homeostasis. Located in trans-Golgi network transport vesicle membrane. Used to study Menkes disease; Wilson disease; occipital horn syndrome; and spinal muscular atrophy. Human ortholog(s) of this gene implicated in Menkes disease; Wilson disease; X-linked distal spinal muscular atrophy 3; cutis laxa; and occipital horn syndrome. Orthologous to several human genes including ATP7A (ATPase copper transporting alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CCC2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1005675..1008689)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ser(258) and Ser(971) are under long-range intramolecular, reciprocal and concerted control, in a sequential process that is crucial for catalysis and copper transport in the yeast copper ATPase
Title: Two serine residues control sequential steps during catalysis of the yeast copper ATPase through different mechanisms that involve kinase-mediated phosphorylations.
evidence of a dual role for the Ccc2 N-terminus, namely to receive copper from Atx1 and to convey copper to another domain of Ccc2, thereby activating the ATPase
Title: Dissecting the role of the N-terminal metal-binding domains in activating the yeast copper ATPase in vivo.
Cyclic AMP-dependent protein kinase (PKA) regulates Ccc2p with PKA-mediated phosphorylation of a conserved serine (Ser258) being crucial for catalysis.
Title: Cyclic AMP-dependent protein kinase controls energy interconversion during the catalytic cycle of the yeast copper-ATPase.
structurally characterized the adduct between the copper chaperone Atx1 and the first copper(I)-binding domain of the Ccc2 ATPase
Title: The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables P-type divalent copper transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type monovalent copper transporter activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in copper ion export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in copper ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in copper ion transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network transport vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Cu(2+)-transporting P-type ATPase CCC2

NP_010556.1

EC 7.2.2.8

Cu(+2)-transporting P-type ATPase; required for export of copper from cytosol into extracytosolic compartment; targeted to vacuole via AP-3 pathway; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; human homologs ATP7A and ATP7B both complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1005675..1008689

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180578.1 → NP_010556.1 TPA: Cu(2+)-transporting P-type ATPase CCC2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010556.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSQ3, P38995

UniProtKB/TrEMBL

B3LG21, C7GS90, C8Z5I3, N1P708

Conserved Domains (2) summary

cd00371
Location:6 → 67

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

cd02094
Location:259 → 938

P-type_ATPase_Cu-like; P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B