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    ATP5 F1F0 ATP synthase subunit 5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851892, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATP5
    Official Full Name
    F1F0 ATP synthase subunit 5
    Primary source
    SGD:S000002706
    Locus tag
    YDR298C
    See related
    AllianceGenome:SGD:S000002706; FungiDB:YDR298C; VEuPathDB:YDR298C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    OSC1
    Summary
    Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in proton motive force-driven ATP synthesis. Located in mitochondrion. Part of proton-transporting ATP synthase, stator stalk. Used to study Leigh disease. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 7. Orthologous to human ATP5PO (ATP synthase peripheral stalk subunit OSCP). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATP5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1058176..1058814, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein MHR1 Neighboring gene sphingosine hydroxylase Neighboring gene rRNA-processing protein BFR2 Neighboring gene glutamate 5-kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterologous expression, purification, and biochemistry of the oligomycin sensitivity conferring protein (OSCP) from yeast. Mukhopadhyay A, et al. J Biol Chem, 1992 Dec 25. PMID 1464586
    2. The gene coding for the yeast oligomycin sensitivity-conferring protein. Uh M, et al. J Biol Chem, 1990 Nov 5. PMID 2146269
    3. Structural interactions of the oligomycin sensitivity-conferring protein in the yeast ATP synthase. Mao Y, et al. Arch Biochem Biophys, 1997 Jan 1. PMID 8990262
    4. Properties of yeast cells depleted of the OSCP subunit of mitochondrial ATP synthase by regulated expression of the ATP5 gene. Prescott M, et al. Biochem Mol Biol Int, 1994 Oct. PMID 7866306
    5. Modulation at a distance of proton conductance through the Saccharomyces cerevisiae mitochondrial F1F0-ATP synthase by variants of the oligomycin sensitivity-conferring protein containing substitutions near the C-terminus. Boyle GM, et al. J Bioenerg Biomembr, 2000 Dec. PMID 15254373

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton motive force-driven mitochondrial ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase, stator stalk IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase, stator stalk IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F1F0 ATP synthase subunit 5
    NP_010584.1
    • Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1058176..1058814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180606.1 → NP_010584.1  TPA: F1F0 ATP synthase subunit 5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010584.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSS7, P09457
      UniProtKB/TrEMBL
      A6ZYP6, B3LFZ7, C7GQU8, C8Z5L0, G2WB36, N1P6U3
      Conserved Domains (1) summary
      pfam00213
      Location:32 → 208
      OSCP; ATP synthase delta (OSCP) subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09457.1

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