PEX3 Pex3p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PEX3
Official Full Name: Pex3p
Primary source: SGD:S000002737
Locus tag: YDR329C
See related: AllianceGenome:SGD:S000002737; FungiDB:YDR329C; VEuPathDB:YDR329C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PAS3
Summary: Enables protein-macromolecule adaptor activity. Involved in ER-dependent peroxisome organization; peroxisome inheritance; and protein import into peroxisome membrane. Located in endoplasmic reticulum and peroxisomal membrane. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 10B and peroxisome biogenesis disorder 10A. Orthologous to human PEX3 (peroxisomal biogenesis factor 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PEX3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1126270..1127595, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Pex3-Inp1 complex tethers yeast peroxisomes to the plasma membrane.
Title: The Pex3-Inp1 complex tethers yeast peroxisomes to the plasma membrane.
Peroxisome retention involves Inp1-dependent peroxisome-plasma membrane contact sites in yeast.
Title: Peroxisome retention involves Inp1-dependent peroxisome-plasma membrane contact sites in yeast.
Pex3 confines pexophagy receptor activity of Atg36 to peroxisomes by regulating Hrr25-mediated phosphorylation and proteasomal degradation.
Title: Pex3 confines pexophagy receptor activity of Atg36 to peroxisomes by regulating Hrr25-mediated phosphorylation and proteasomal degradation.
Using a combination of microscopy and biochemical approaches, we show that a subset of the PMPs, including the receptor docking protein Pex14, localizes to membrane vesicles in S. cerevisiae pex3 cells.
Title: Saccharomyces cerevisiae cells lacking Pex3 contain membrane vesicles that harbor a subset of peroxisomal membrane proteins.
a shift to shorter (C18-->C16) acyl chains contributes to the reduced binding of alphaS to lipid droplets in pex3Delta cells
Title: A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeast.
It was concluded that Pex3 recruits the pexophagy receptor Atg36. This reinforces the pivotal role played by Pex3 in coordinating the size of the peroxisome pool, and establishes its role in pexophagy in S. cerevisiae.
Title: Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae.
Data conclude that natural or artificial targeting of Pex3p to any endomembrane may initiate peroxisome formation and that also Pex3p-containing mitochondria can serve as source for the de novo synthesis of peroxisomes.
Title: De novo synthesis of peroxisomes upon mitochondrial targeting of Pex3p.
Pex3p functions as an anchor for inheritance protein Inp1p at the peroxisomal membrane, independently of its role at the endoplasmic reticulum in peroxisome biogenesis.
Title: A dual function for Pex3p in peroxisome formation and inheritance.
The N-domain of Pex22p can functionally replace the Pex3p N-domain in targeting and peroxisome formation.
Title: The N-domain of Pex22p can functionally replace the Pex3p N-domain in targeting and peroxisome formation.
Pex3p amino-terminal domain targets to a subdomain of the endoplasmic reticulum and initiates the formation of a preperoxisomal compartment for de novo peroxisome synthesis; peroxisome formation depends on the activity of the genes PEX14 and PEX19
Title: Pex3p initiates the formation of a preperoxisomal compartment from a subdomain of the endoplasmic reticulum in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-macromolecule adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ER-dependent peroxisome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in ER-dependent peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into peroxisome membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Pex3p

NP_010616.3

Peroxisomal membrane protein (PMP); required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p