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    UBX5 Ubx5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UBX5
    Official Full Name
    Ubx5p
    Primary source
    SGD:S000002738
    Locus tag
    YDR330W
    See related
    AllianceGenome:SGD:S000002738; FungiDB:YDR330W; VEuPathDB:YDR330W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ubiquitin binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Orthologous to human UBXN7 (UBX domain protein 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See UBX5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1127872..1129374)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene SCF ubiquitin ligase subunit SKP1 Neighboring gene Pex3p Neighboring gene GPI-anchor transamidase Neighboring gene double-stranded DNA-dependent ATPase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knowledge-based analysis of microarray gene expression data by using support vector machines. Brown MP, et al. Proc Natl Acad Sci U S A, 2000 Jan 4. PMID 10618406, Free PMC Article
    2. ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors. Marshall RS, et al. Cell, 2019 Apr 18. PMID 30955882, Free PMC Article
    3. Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation. Li H, et al. Mol Cell, 2024 Apr 4. PMID 38401542
    4. The UBX domain: a widespread ubiquitin-like module. Buchberger A, et al. J Mol Biol, 2001 Mar 16. PMID 11243799
    5. Ubx5-Cdc48 assists the protease Wss1 at DNA-protein crosslink sites in yeast. Noireterre A, et al. EMBO J, 2023 Jul 3. PMID 37144685, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ubx5p
    NP_010617.1
    • UBX domain-containing protein that interacts with Cdc48p; ubiquitin regulatory X is also known as UBX

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1127872..1129374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180638.1 → NP_010617.1  TPA: Ubx5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010617.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSW2, Q06682
      UniProtKB/TrEMBL
      A6ZYT2, B3LFW7, B5VGL3, C7GWM7, G2WB69, N1PAI0
      Conserved Domains (3) summary
      smart00166
      Location:419 → 494
      UBX; Domain present in ubiquitin-regulatory proteins
      cd02958
      Location:219 → 336
      UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
      cd14346
      Location:3 → 41
      UBA_Ubx5_like; UBA-like domain found in Saccharomyces cerevisiae UBX domain-containing protein 5 (Ubx5) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06682.1

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