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    GPI8 GPI-anchor transamidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851931, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GPI8
    Official Full Name
    GPI-anchor transamidase
    Primary source
    SGD:S000002739
    Locus tag
    YDR331W
    See related
    AllianceGenome:SGD:S000002739; FungiDB:YDR331W; VEuPathDB:YDR331W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GPI-anchor transamidase activity. Involved in attachment of GPI anchor to protein. Located in endoplasmic reticulum membrane. Part of GPI-anchor transamidase complex. Orthologous to human PIGK (phosphatidylinositol glycan anchor biosynthesis class K). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GPI8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1129588..1130823)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pex3p Neighboring gene Ubx5p Neighboring gene double-stranded DNA-dependent ATPase Neighboring gene Rqc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Truncation of the caspase-related subunit (Gpi8p) of Saccharomyces cerevisiae GPI transamidase: dimerization revealed. Meitzler JL, et al. Arch Biochem Biophys, 2007 Jun 1. PMID 17475206
    2. Structural insight into the glycosylphosphatidylinositol transamidase subunits PIG-K and PIG-S from yeast. Toh YK, et al. J Struct Biol, 2011 Feb. PMID 21134462
    3. Yeast Gpi8p is essential for GPI anchor attachment onto proteins. Benghezal M, et al. EMBO J, 1996 Dec 2. PMID 8978684, Free PMC Article
    4. The soluble domains of Gpi8 and Gaa1, two subunits of glycosylphosphatidylinositol transamidase (GPI-T), assemble into a complex. Gamage DG, et al. Arch Biochem Biophys, 2017 Nov 1. PMID 28893510
    5. Identification of six complementation classes involved in the biosynthesis of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae. Benghezal M, et al. J Cell Biol, 1995 Sep. PMID 7559756, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The soluble domains of Gpi8 and Gaa1, two subunits of glycosylphosphatidylinositol transamidase, assemble into a complex.
      Title: The soluble domains of Gpi8 and Gaa1, two subunits of glycosylphosphatidylinositol transamidase (GPI-T), assemble into a complex.
    2. analysis of truncation of Gpi8p of Saccharomyces cerevisiae GPI transamidase
      Title: Truncation of the caspase-related subunit (Gpi8p) of Saccharomyces cerevisiae GPI transamidase: dimerization revealed.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GPI-anchor transamidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GPI-anchor transamidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GPI-anchor transamidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of GPI anchor to protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of GPI anchor to protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GPI-anchor transamidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GPI-anchor transamidase
    NP_010618.1
    • Catalytic subunit of the ER membrane GPI transamidase complex; involved in adding glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; luminally-oriented type I integral membrane glycoprotein of the ER; human PIGK protein is a functional homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1129588..1130823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180639.1 → NP_010618.1  TPA: GPI-anchor transamidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010618.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSW3, P49018
      UniProtKB/TrEMBL
      A6ZYT3, C7GWM8, C8Z5P3, G2WB70, N1P770
      Conserved Domains (1) summary
      COG5206
      Location:2 → 407
      GPI8; Glycosylphosphatidylinositol transamidase (GPIT), subunit GPI8 [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49018.1

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