U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RQC1 Rqc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851933, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RQC1
    Official Full Name
    Rqc1p
    Primary source
    SGD:S000002741
    Locus tag
    YDR333C
    See related
    AllianceGenome:SGD:S000002741; FungiDB:YDR333C; VEuPathDB:YDR333C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-macromolecule adaptor activity. Involved in rescue of stalled ribosome and ribosome-associated ubiquitin-dependent protein catabolic process. Located in cytoplasm. Part of RQC complex. Orthologous to human TCF25 (transcription factor 25). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RQC1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1133260..1135431, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene GPI-anchor transamidase Neighboring gene double-stranded DNA-dependent ATPase Neighboring gene chromatin-remodeling protein SWR1 Neighboring gene karyopherin MSN5

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing. Osuna BA, et al. Elife, 2017 Jul 18. PMID 28718767, Free PMC Article
    2. Failure of RQC machinery causes protein aggregation and proteotoxic stress. Choe YJ, et al. Nature, 2016 Mar 10. PMID 26934223
    3. Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex. Yang J, et al. Elife, 2016 Apr 1. PMID 27033550, Free PMC Article
    4. Vms1p is a release factor for the ribosome-associated quality control complex. Zurita Rendón O, et al. Nat Commun, 2018 Jun 6. PMID 29875445, Free PMC Article
    5. Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1. Zheng J, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28864412

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rqc1 and other yeast proteins containing highly positively charged sequences are not targets of the RQC complex.
      Title: Rqc1 and other yeast proteins containing highly positively charged sequences are not targets of the RQC complex.
    2. The authors determined that the Rqc2p-mediated Carboxy-terminal Alanine and Threonine (CAT) tail elongation is mechanistically distinct from canonical translation, that Ltn1p-mediated ubiquitination depends on the poorly characterized Ribosome-associated Quality control Complex (RQC) component Rqc1p, and that the process of CAT tailing enables robust ubiquitination of the nascent polypeptide.
      Title: In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing.
    3. Data show that Saccharomyces cerevisiae proteins Rqc1, Ltn1, and Cdc48 prevent the aggregation of aberrant proteins that can only appear after C-terminal alanine-threonine tail (CAT-tail) addition by Rqc2.
      Title: Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in rescue of stalled ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rescue of stalled ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rescue of stalled ribosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RQC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RQC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RQC complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Rqc1p
    NP_010620.3
    • Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Rqc2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Rkr1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1133260..1135431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180641.3 → NP_010620.3  TPA: Rqc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010620.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSW5, Q05468
      UniProtKB/TrEMBL
      A6ZYT5, B3LFW4, B5VGL6, C7GWN0, C8Z5P5, N1P6Y5
      Conserved Domains (1) summary
      pfam04910
      Location:327 → 663
      Tcf25; Transcriptional repressor TCF25
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05468.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools