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    SVF1 Svf1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851947, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SVF1
    Official Full Name
    Svf1p
    Primary source
    SGD:S000002754
    Locus tag
    YDR346C
    See related
    AllianceGenome:SGD:S000002754; FungiDB:YDR346C; VEuPathDB:YDR346C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SGI1
    Summary
    Enables ceramide binding activity. Involved in cellular response to oxidative stress. Acts upstream of or within sphingolipid biosynthetic process. Located in cis-Golgi network. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SVF1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1167214..1168659, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hexose transporter HXT3 Neighboring gene mitochondrial 37S ribosomal protein MRP1 Neighboring gene Pal1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Svf1 inhibits reactive oxygen species generation and promotes survival under conditions of oxidative stress in Saccharomyces cerevisiae. Brace JL, et al. Yeast, 2005 Jun. PMID 16034825
    2. Yeast Svf1 binds ceramides and contributes to sphingolipid metabolism at the ER cis-Golgi interface. Limar S, et al. J Cell Biol, 2023 May 1. PMID 36897280, Free PMC Article
    3. Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. Vander Heiden MG, et al. J Biol Chem, 2002 Nov 22. PMID 12244097
    4. SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae. Brace JL, et al. Genetics, 2007 Jan. PMID 17057230, Free PMC Article
    5. Yeast surviving factor Svf1 as a new interacting partner, regulator and in vitro substrate of protein kinase CK2. Masłyk M, et al. Mol Cell Biochem, 2008 May. PMID 18265947

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast Svf1 binds ceramides and contributes to sphingolipid metabolism at the ER cis-Golgi interface.
      Title: Yeast Svf1 binds ceramides and contributes to sphingolipid metabolism at the ER cis-Golgi interface.
    2. CK2 phosphorylates up to six serine residues in highly acidic peptide K199EVIPESDEEESSADEDDNEDEDEESGDSEEESGSEEESDSEEVEITYED248 of the Svf1 protein in vitro.
      Title: Yeast surviving factor Svf1 as a new interacting partner, regulator and in vitro substrate of protein kinase CK2.
    3. required for yeast survival under conditions of oxidative stress and cold stress, and inhibits reactive oxygen species production
      Title: Svf1 inhibits reactive oxygen species generation and promotes survival under conditions of oxidative stress in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ceramide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sphingolipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Svf1p
    NP_010633.3
    • Ceramide binding protein; putative ceramide transfer protein involved in the nonvesicular transport of ceramides between the endoplasmic reticulum and Golgi apparatus; contributes to sphingolipid biosynthesis at the cis-Golgi; localizes to the cis-Golgi and the cytoplasm; required for the diauxic growth shift; promotes survival in mammalian cells under apoptosis-inducing conditions; mutant has increased aneuploidy tolerance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1167214..1168659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180654.3 → NP_010633.3  TPA: Svf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010633.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSX6, Q05515
      UniProtKB/TrEMBL
      A6ZYU6, B3LFV4, C8Z5Q7, N1P6Z6
      Conserved Domains (2) summary
      pfam08622
      Location:56 → 202
      Svf1; Svf1-like N-terminal lipocalin domain
      pfam17187
      Location:270 → 468
      Svf1_C; Svf1-like C-terminal lipocalin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05515.1

    Gene LinkOut

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