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    MRP1 mitochondrial 37S ribosomal protein MRP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851948, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MRP1
    Official Full Name
    mitochondrial 37S ribosomal protein MRP1
    Primary source
    SGD:S000002755
    Locus tag
    YDR347W
    See related
    AllianceGenome:SGD:S000002755; FungiDB:YDR347W; VEuPathDB:YDR347W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    mS43
    Summary
    A structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Part of mitochondrial small ribosomal subunit. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MRP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1169178..1170143)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hexose transporter HXT3 Neighboring gene Svf1p Neighboring gene Pal1p Neighboring gene putative aspartic endopeptidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discoordinate expression of the yeast mitochondrial ribosomal protein MRP1. Dang H, et al. J Biol Chem, 1990 May 5. PMID 2185247
    2. Nucleotide sequence analyses of the MRP1 gene in four populations suggest negative selection on its coding region. Wang Z, et al. BMC Genomics, 2006 May 10. PMID 16684361, Free PMC Article
    3. Allosteric interactions between the two non-equivalent nucleotide binding domains of multidrug resistance protein MRP1. Hou Y, et al. J Biol Chem, 2000 Jul 7. PMID 10781583
    4. Assembly of the mitochondrial membrane system. MRP1 and MRP2, two yeast nuclear genes coding for mitochondrial ribosomal proteins. Myers AM, et al. J Biol Chem, 1987 Mar 5. PMID 3029111
    5. Polarized macrophage subsets differentially express the drug efflux transporters MRP1 and BCRP, resulting in altered HIV production. He H, et al. Antivir Chem Chemother, 2018 Jan-Dec. PMID 29343083, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results support our hypothesis that there is differential expression of MRP1 and BCRP on M1 and M2 polarized macrophages and suggests that these differences may result in altered intracellular concentrations of antiretrovirals in macrophages and alter viral production in these cells; targeting these differences may be a strategy to decrease viral replication in HIV-infected individuals
      Title: Polarized macrophage subsets differentially express the drug efflux transporters MRP1 and BCRP, resulting in altered HIV production.
    2. To facilitate association studies of this gene with diseases and/or drug response, exons and flanking introns of MRP1 were screened for polymorphisms in 142 DNA samples from four different populations.
      Title: Nucleotide sequence analyses of the MRP1 gene in four populations suggest negative selection on its coding region.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial 37S ribosomal protein MRP1
    NP_010634.3
    • Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1169178..1170143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180655.3 → NP_010634.3  TPA: mitochondrial 37S ribosomal protein MRP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010634.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSX7, P10662
      UniProtKB/TrEMBL
      A6ZYU7, B3LFV3, C7GXA3, C8Z5Q8, G2WB85, N1P5B6
      Conserved Domains (1) summary
      COG0605
      Location:20 → 315
      SodA; Superoxide dismutase [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10662.2

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