GLE2 RNA export factor GLE2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GLE2
Official Full Name: RNA export factor GLE2
Primary source: SGD:S000000909
Locus tag: YER107C
See related: AllianceGenome:SGD:S000000909; FungiDB:YER107C; VEuPathDB:YER107C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RAE1
Summary: Predicted to enable RNA binding activity and ubiquitin binding activity. Involved in several processes, including nuclear pore localization; poly(A)+ mRNA export from nucleus; and post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Located in cytoplasm. Part of nuclear pore. Orthologous to human RAE1 (ribonucleic acid export 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GLE2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (373448..374545, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gle2 participates in the efficient organization of the septin assembly network, where it might act as a scaffold protein.
Title: Saccharomyces cerevisiae Gle2/Rae1 is involved in septin organization, essential for cell cycle progression.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear pore localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in poly(A)+ mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA export from nucleus in response to heat stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA export factor GLE2

NP_011033.3

RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

373448..374545 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178998.3 → NP_011033.3 TPA: RNA export factor GLE2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011033.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DM14, P40066

UniProtKB/TrEMBL

A6ZR63, B3LRM4, C7GS78, C8Z7C5, G2WD16, N1P734

Conserved Domains (2) summary

sd00039
Location:39 → 78

7WD40; WD40 repeat [structural motif]

cl29593
Location:36 → 333

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...