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    LCL3 Lcl3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852795, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LCL3
    Official Full Name
    Lcl3p
    Primary source
    SGD:S000003053
    Locus tag
    YGL085W
    See related
    AllianceGenome:SGD:S000003053; FungiDB:YGL085W; VEuPathDB:YGL085W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable endonuclease activity and metal ion binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LCL3 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (349616..350440)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene E2 ubiquitin-conjugating protein MMS2 Neighboring gene coiled-coil domain-containing protein MAD1 Neighboring gene O-acyltransferase Neighboring gene Scy1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A microarray-based genetic screen for yeast chronological aging factors. Matecic M, et al. PLoS Genet, 2010 Apr 22. PMID 20421943, Free PMC Article
    2. Global protein expression profiling of budding yeast in response to DNA damage. Lee MW, et al. Yeast, 2007 Mar. PMID 17351896
    3. P100, a transcriptional coactivator, is a human homologue of staphylococcal nuclease. Ponting CP. Protein Sci, 1997 Feb. PMID 9041650, Free PMC Article
    4. The yeast Ess1 prolyl isomerase controls Swi6 and Whi5 nuclear localization. Atencio D, et al. G3 (Bethesda), 2014 Mar 20. PMID 24470217, Free PMC Article
    5. Association of yeast Upf1p with direct substrates of the NMD pathway. Johansson MJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 26. PMID 18087042, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lcl3p
    NP_011430.1
    • hypothetical protein; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      349616..350440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180950.1 → NP_011430.1  TPA: Lcl3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011430.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZU94, B3LHF1, B5VIN9, C7GW31, C8Z8G3, D6VU59, P53153
      UniProtKB/TrEMBL
      G2WE14, N1P3J5
      Conserved Domains (1) summary
      pfam00565
      Location:149 → 261
      SNase; Staphylococcal nuclease homolog
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53153.1

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