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    TOS8 Tos8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852783, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TOS8
    Official Full Name
    Tos8p
    Primary source
    SGD:S000003064
    Locus tag
    YGL096W
    See related
    AllianceGenome:SGD:S000003064; FungiDB:YGL096W; VEuPathDB:YGL096W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables chromatin binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in chromatin. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; cleft palate, cardiac defects, and intellectual disabillity; holoprosencephaly (multiple); open-angle glaucoma; and orofacial cleft (multiple). Orthologous to several human genes including MEIS1 (Meis homeobox 1); MEIS2 (Meis homeobox 2); and MEIS3 (Meis homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TOS8 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (325331..326161)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene Ran guanyl-nucleotide exchange factor Neighboring gene tRNA-Glu Neighboring gene Vps45p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption and phenotypic analysis of six open reading frames from the left arm of Saccharomyces cerevisiae chromosome VII. Lillo JA, et al. Yeast, 2000 Mar 15. PMID 10669874
    2. Transcriptional Profiling of Biofilm Regulators Identified by an Overexpression Screen in Saccharomyces cerevisiae. Cromie GA, et al. G3 (Bethesda), 2017 Aug 7. PMID 28673928, Free PMC Article
    3. Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Horak CE, et al. Genes Dev, 2002 Dec 1. PMID 12464632, Free PMC Article
    4. Dynamics of Cdk1 substrate specificity during the cell cycle. Kõivomägi M, et al. Mol Cell, 2011 Jun 10. PMID 21658602, Free PMC Article
    5. Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library. Youn JY, et al. G3 (Bethesda), 2017 Mar 10. PMID 28122947, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tos8p
    NP_011419.1
    • Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      325331..326161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180961.1 → NP_011419.1  TPA: Tos8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011419.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU49, P53147
      UniProtKB/TrEMBL
      A6ZU84, B3LHG1, C8Z8F2, N1P9P8
      Conserved Domains (1) summary
      pfam05920
      Location:212 → 251
      Homeobox_KN; Homeobox KN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53147.1

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