ARO2 bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ARO2
Official Full Name: bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2
Primary source: SGD:S000003116
Locus tag: YGL148W
See related: AllianceGenome:SGD:S000003116; FungiDB:YGL148W; VEuPathDB:YGL148W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables chorismate synthase activity and riboflavin reductase (NADPH) activity. Involved in aromatic amino acid family biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ARO2 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (226399..227529)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables FMN binding	IBA Inferred from Biological aspect of Ancestor more info
enables FMN reductase (NAD(P)H) activity	IEA Inferred from Electronic Annotation more info
enables FMN reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables chorismate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chorismate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables chorismate synthase activity	IEA Inferred from Electronic Annotation more info
enables chorismate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables riboflavin reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in aromatic amino acid family biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in aromatic amino acid family biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in aromatic amino acid family biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chorismate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chorismate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2

NP_011367.1

EC 1.5.1.38

EC 4.2.3.5

Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

226399..227529

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181013.1 → NP_011367.1 TPA: bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011367.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VU01, P28777

UniProtKB/TrEMBL

A6ZU35, B3LHK3, B5VII2, C7GPQ5, C8Z8A2, G2WDV5, N1P2X6

Conserved Domains (1) summary

TIGR00033
Location:8 → 369

aroC; chorismate synthase