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    EMC4 chaperone EMC4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852620, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EMC4
    Official Full Name
    chaperone EMC4
    Primary source
    SGD:S000003200
    Locus tag
    YGL231C
    See related
    AllianceGenome:SGD:S000003200; FungiDB:YGL231C; VEuPathDB:YGL231C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein folding in endoplasmic reticulum. Located in endoplasmic reticulum. Part of EMC complex. Orthologous to human EMC4 (ER membrane protein complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EMC4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (63048..63620, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rab GTPase-binding exocyst subunit SEC15 Neighboring gene putative tRNA acetyltransferase Neighboring gene uncharacterized protein Neighboring gene Sap4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast. Ring G, et al. FEBS Lett, 2008 Jul 23. PMID 18586032
    2. Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays a crucial role in eIF2B-mediated translation regulation and survival under stress conditions. Sharma S, et al. J Genet Eng Biotechnol, 2020 Jun 1. PMID 32476094, Free PMC Article
    3. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
    4. Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Richard M, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431131, Free PMC Article
    5. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of the yeast TMEM85 ortholog YGL231c leads to increased resistance to oxidative stress.
      Title: Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding in endoplasmic reticulum HGI PubMed 
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chaperone EMC4
    NP_011283.1
    • Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4 and fly CG11137; mutation is functionally complemented by human EMC4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      63048..63620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181097.1 → NP_011283.1  TPA: chaperone EMC4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011283.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVA3, P53073
      UniProtKB/TrEMBL
      A6ZTV9, B3LHS4, B5VIB2, C7GNX8, C8Z824, G2WDM8, N1P3W9
      Conserved Domains (1) summary
      pfam06417
      Location:60 → 176
      DUF1077; Protein of unknown function (DUF1077)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53073.1

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