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    HSV2 Hsv2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853138, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HSV2
    Official Full Name
    Hsv2p
    Primary source
    SGD:S000003455
    Locus tag
    YGR223C
    See related
    AllianceGenome:SGD:S000003455; FungiDB:YGR223C; VEuPathDB:YGR223C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatidylinositol phosphate binding activity. Involved in piecemeal microautophagy of the nucleus. Located in endosome and fungal-type vacuole. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Orthologous to several human genes including WDR45B (WD repeat domain 45B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HSV2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (940869..942215, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Pet54p Neighboring gene azole transporter Neighboring gene Ama1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of PROPPIN-Phosphoinositide Binding and Role of Loop 6CD in PROPPIN-Membrane Binding. Busse RA, et al. Biophys J, 2015 May 5. PMID 25954880, Free PMC Article
    2. A quantitative liposome microarray to systematically characterize protein-lipid interactions. Saliba AE, et al. Nat Methods, 2014 Jan. PMID 24270602
    3. Two-site recognition of phosphatidylinositol 3-phosphate by PROPPINs in autophagy. Baskaran S, et al. Mol Cell, 2012 Aug 10. PMID 22704557, Free PMC Article
    4. Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family. Krick R, et al. Proc Natl Acad Sci U S A, 2012 Jul 24. PMID 22753491, Free PMC Article
    5. Dissecting the localization and function of Atg18, Atg21 and Ygr223c. Krick R, et al. Autophagy, 2008 Oct. PMID 18769150

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,5-bisphosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-5-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy of peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein lipidation involved in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Hsv2p
    NP_011739.1
    • Phosphoinositide (PI) binding protein; involved in micronucleophagy; belongs to the PROPPIN family of proteins defined by a seven-bladed beta-propeller fold and FRRG motif required for PI binding; displays punctate cytoplasmic localization

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      940869..942215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181352.1 → NP_011739.1  TPA: Hsv2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011739.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV05, P50079
      UniProtKB/TrEMBL
      A6ZUN3, B3LI15, B5VJG2, G2WEV1, N1P651
      Conserved Domains (2) summary
      sd00039
      Location:228 → 267
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:220 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50079.1

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