NAS6 Nas6p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NAS6
Official Full Name: Nas6p
Primary source: SGD:S000003464
Locus tag: YGR232W
See related: AllianceGenome:SGD:S000003464; FungiDB:YGR232W; VEuPathDB:YGR232W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables proteasome regulatory particle binding activity and protein folding chaperone. Involved in proteasome regulatory particle assembly. Located in cytosol and nucleus. Orthologous to human PSMD10 (proteasome 26S subunit, non-ATPase 10). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NAS6 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (953960..954646)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Assembly chaperone Nas6 selectively destabilizes 26S proteasomes with defective regulatory particle-core particle interfaces.
Title: Assembly chaperone Nas6 selectively destabilizes 26S proteasomes with defective regulatory particle-core particle interfaces.
Nas6 is evicted from nascent proteasomes during completion of assembly via a conformation-specific allosteric interaction of the Rpn5 subunit with the proteasomal ATPase ring.
Title: An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes.
Data suggest that Nas6 provides a finely regulated mechanism to order the events of proteasome assembly in time.
Title: Nucleotide-dependent switch in proteasome assembly mediated by the Nas6 chaperone.
Data show that both ATPases Rpt6 and Rpt3 tails are required for the eviction of Nas6 chaperone upon proteasome assembly.
Title: Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly.
provide a structural basis for the association between Nas6 and the heterohexameric ATPase ring of the proteasome through Rpt3
Title: Structural basis for the recognition between the regulatory particles Nas6 and Rpt3 of the yeast 26S proteasome.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables proteasome regulatory particle binding	IDA Inferred from Direct Assay more info	PubMed
enables protein folding chaperone	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome regulatory particle assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome regulatory particle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Nas6p

NP_011748.3

Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, also known as p28, which interacts with the Rb tumor suppressor and CDK4/6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

953960..954646

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181361.3 → NP_011748.3 TPA: Nas6p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011748.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VV12, P50086

UniProtKB/TrEMBL

C7GNJ7, G2WEV8, N1P2L0

Conserved Domains (2) summary

COG0666
Location:1 → 226

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:107 → 137

ANK; ANK repeat [structural motif]