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    PHO81 Pho81p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853148, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PHO81
    Official Full Name
    Pho81p
    Primary source
    SGD:S000003465
    Locus tag
    YGR233C
    See related
    AllianceGenome:SGD:S000003465; FungiDB:YGR233C; VEuPathDB:YGR233C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VAC6
    Summary
    Enables cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in cellular response to phosphate starvation and phosphate-containing compound metabolic process. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PHO81 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (954674..958210, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene prohibitin subunit PHB2 Neighboring gene Nas6p Neighboring gene flavohemoglobin Neighboring gene Mic26p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP(8) and the SPX domain of Pho81. Chabert V, et al. Elife, 2023 Sep 20. PMID 37728314, Free PMC Article
    2. Discovery of mutations in Saccharomyces cerevisiae by pooled linkage analysis and whole-genome sequencing. Birkeland SR, et al. Genetics, 2010 Dec. PMID 20923977, Free PMC Article
    3. Functional Analysis of the Upstream Sequence of PHO81 Gene of Saccharomyces cerevisiae. Xia ZX, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 1999. PMID 12142922
    4. Functional Domains of the Regulatory Factor PHO81 of Saccharomyces cerevisiae. Wu JS, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 1996. PMID 12232612
    5. Promoter analysis of the PHO81 gene encoding a 134 kDa protein bearing ankyrin repeats in the phosphatase regulon of Saccharomyces cerevisiae. Ogawa N, et al. Mol Gen Genet, 1993 Apr. PMID 8492812

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81.
      Title: Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP(8) and the SPX domain of Pho81.
    2. Full-length Pho81 is required to control trehalose metabolism and the PDS targets in Saccharomyces.
      Title: The minimum domain of Pho81 is not sufficient to control the Pho85-Rim15 effector branch involved in phosphate starvation-induced stress responses.
    3. myo-d-inositol heptakisphosphate is necessary for Pho81-dependent inhibition of Pho80-Pho85 in vitro; fndings reveal regulation of a cyclin-CDK complex by a metabolite & suggest that a complex metabolic network mediates signaling of phosphate availability
      Title: Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to phosphate starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphate-containing compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pho81p
    NP_011749.3
    • Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      954674..958210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181362.3 → NP_011749.3  TPA: Pho81p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011749.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV13, P17442, Q06887
      UniProtKB/TrEMBL
      G2WEV9, N1P9Y8
      Conserved Domains (5) summary
      PHA02875
      Location:466 → 650
      PHA02875; ankyrin repeat protein; Provisional
      cd08578
      Location:875 → 1172
      GDPD_NUC-2_fungi; Putative glycerophosphodiester phosphodiesterase domain of ankyrin repeat protein NUC-2 and similar proteins
      cd14483
      Location:2 → 159
      SPX_PHO81_NUC-2_like; SPX domain of Pho81, NUC-2, and similar proteins
      sd00045
      Location:561 → 588
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:561 → 647
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17442.2

    Gene LinkOut

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