VMA16 H(+)-transporting V0 sector ATPase subunit c'' [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: VMA16
Official Full Name: H(+)-transporting V0 sector ATPase subunit c''
Primary source: SGD:S000001068
Locus tag: YHR026W
See related: AllianceGenome:SGD:S000001068; FungiDB:YHR026W; VEuPathDB:YHR026W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PPA1
Summary: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in vacuolar acidification. Located in membrane. Orthologous to human ATP6V0B (ATPase H+ transporting V0 subunit b). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See VMA16 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (160844..161485)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Subunit c'' of the vacuolar H+-ATPase (V-ATPase) is not essential for assembly of the V-ATPase complex but is required for the functional coupling of the two domains of V-ATPase.
Title: Assembly of the yeast vacuolar H+-ATPase and ATP hydrolysis occurs in the absence of subunit c''.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vacuolar acidification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	TAS Traceable Author Statement more info	PubMed
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: H(+)-transporting V0 sector ATPase subunit c''

NP_011891.1

Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

160844..161485

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179156.1 → NP_011891.1 TPA: H(+)-transporting V0 sector ATPase subunit c'' [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011891.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DKX3, P23968

UniProtKB/TrEMBL

A6ZST2, B3LSE7, C7GTV4, C8ZA94, G2WF97, N1P387

Conserved Domains (2) summary

cd18177
Location:59 → 121

ATP-synt_Vo_c_ATP6F_rpt1; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins

cd18178
Location:141 → 192

ATP-synt_Vo_c_ATP6F_rpt2; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins