STE12 homeodomain family transcription factor STE12 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: STE12
Official Full Name: homeodomain family transcription factor STE12
Primary source: SGD:S000001126
Locus tag: YHR084W
See related: AllianceGenome:SGD:S000001126; FungiDB:YHR084W; VEuPathDB:YHR084W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA-binding transcription factor activity. Involved in several processes, including invasive growth in response to glucose limitation; pseudohyphal growth; and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of Ste12p-Dig1p-Dig2p complex and Tec1p-Ste12p-Dig1p complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See STE12 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (274174..276240)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tec1 and Ste12 transcription factors play a role in adaptation to low pH stress and biofilm formation in the human opportunistic fungal pathogen Candida glabrata.
Title: Tec1 and Ste12 transcription factors play a role in adaptation to low pH stress and biofilm formation in the human opportunistic fungal pathogen Candida glabrata.
Overexpression of the wild-type CAF20 showed an increased protein level of Ste12 transcription factor as well as highly developed P-body formation.
Title: Roles of eIF4E-binding protein Caf20 in Ste12 translation and P-body formation in yeast.
The Q/P-rich C-terminal region of Dhh1 was dispensable for growth at nonpermissive temperature 37 degrees C but appeared to play an important role in regulating the Ste12 protein expression and mating processes
Title: Mutational analysis of the RNA helicase Dhh1 in Ste12 expression and yeast mating.
Collectively, our results implicate Ste12 and Tec1 as general and important contributors to the Cdk8, RNAPII-CTD regulatory circuitry as it relates to the maintenance of genome integrity
Title: The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition.
the transcriptional repressors Dig1 and Dig2 positively affect transcription by stabilizing Ste12
Title: Positive roles for negative regulators in the mating response of yeast.
Ste12-dependent transcription at the centromere is repressed by Dig1 protein.
Title: Endogenous transcription at the centromere facilitates centromere activity in budding yeast.
Data suggest that Tec1 is able to regulate TCS-mediated gene expression by Ste12-dependent and Ste12-independent mechanisms that enable promoter-specific transcriptional control.
Title: The TEA transcription factor Tec1 confers promoter-specific gene regulation by Ste12-dependent and -independent mechanisms.
for many pheromone-responsive genes, Ste12 must activate transcription by binding to cryptic or sub-optimal sites on DNA, or may require interaction with additional uncharacterized DNA bound factors
Title: Organizational constraints on Ste12 cis-elements for a pheromone response in Saccharomyces cerevisiae.
identification of extensive Ste12-binding variation among individuals, and mapped underlying cis- and trans-acting loci responsible for such variation
Title: Genetic analysis of variation in transcription factor binding in yeast.
Ste12 forms two distinct complexes, Ste12/Dig1/Dig2 and Tec1/Ste12/Dig1, both in vivo and in vitro, to regulate mating and filamentation genes.
Title: Regulation of mating and filamentation genes by two distinct Ste12 complexes in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in conjugation with cellular fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in invasive growth in response to glucose limitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pseudohyphal growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of pseudohyphal growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to pheromone	IEA Inferred from Electronic Annotation more info
involved_in sexual reproduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Ste12p-Dig1p-Dig2p complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ste12p-Dig1p-Dig2p complex	IDA Inferred from Direct Assay more info	PubMed
part_of Tec1p-Ste12p-Dig1p complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Tec1p-Ste12p-Dig1p complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeodomain family transcription factor STE12

NP_011952.1

Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

274174..276240

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179214.1 → NP_011952.1 TPA: homeodomain family transcription factor STE12 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011952.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DL35, P13574

UniProtKB/TrEMBL

A6ZSZ3, B3LSK1, C7GWU7, C8Z9M8, N1P2P4

Conserved Domains (1) summary

pfam02200
Location:58 → 167

STE; STE like transcription factor