MSR1 arginine--tRNA ligase MSR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MSR1
Official Full Name: arginine--tRNA ligase MSR1
Primary source: SGD:S000001133
Locus tag: YHR091C
See related: AllianceGenome:SGD:S000001133; FungiDB:YHR091C; VEuPathDB:YHR091C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable arginine-tRNA ligase activity. Involved in mitochondrial translation. Located in mitochondrion. Used to study pontocerebellar hypoplasia type 6. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MSR1 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (284839..286770, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Investigation in yeast of novel variants in mitochondrial aminoacyl-tRNA synthetases WARS2, NARS2, and RARS2 genes associated with mitochondrial diseases.
Title: Investigation in yeast of novel variants in mitochondrial aminoacyl-tRNA synthetases WARS2, NARS2, and RARS2 genes associated with mitochondrial diseases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables arginine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arginine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables arginine-tRNA ligase activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in arginyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in arginyl-tRNA aminoacylation	ISA Inferred from Sequence Alignment more info	PubMed
involved_in mitochondrial arginyl-tRNA aminoacylation	IC Inferred by Curator more info	PubMed
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: arginine--tRNA ligase MSR1

NP_011959.1

EC 6.1.1.19

Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

284839..286770 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179221.1 → NP_011959.1 TPA: arginine--tRNA ligase MSR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011959.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DL43, P38714

UniProtKB/TrEMBL

A6ZT01, B3LSK9, B5VK21

Conserved Domains (1) summary

TIGR00456
Location:69 → 643

argS; arginyl-tRNA synthetase