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    CSM2 Csm2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CSM2
    Official Full Name
    Csm2p
    Primary source
    SGD:S000001394
    Locus tag
    YIL132C
    See related
    AllianceGenome:SGD:S000001394; FungiDB:YIL132C; VEuPathDB:YIL132C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in DNA recombinase assembly; maintenance of rDNA; and meiotic chromosome segregation. Located in site of double-strand break. Part of Shu complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CSM2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (99860..100501, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene flavin adenine dinucleotide transporter FLX1 Neighboring gene ribosomal 60S subunit protein L16A Neighboring gene forkhead family transcription factor FKH1 Neighboring gene Asg1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions. Bonilla B, et al. Elife, 2021 Nov 1. PMID 34723799, Free PMC Article
    2. Genome Profiling for Aflatoxin B(1) Resistance in Saccharomyces cerevisiae Reveals a Role for the CSM2/SHU Complex in Tolerance of Aflatoxin B(1)-Associated DNA Damage. St John N, et al. G3 (Bethesda), 2020 Nov 5. PMID 32994210, Free PMC Article
    3. Structural analysis of Shu proteins reveals a DNA binding role essential for resisting damage. Tao Y, et al. J Biol Chem, 2012 Jun 8. PMID 22465956, Free PMC Article
    4. Structural and SAXS analysis of the budding yeast SHU-complex proteins. She Z, et al. FEBS Lett, 2012 Jul 30. PMID 22749910
    5. The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination. Godin S, et al. Nucleic Acids Res, 2013 Apr. PMID 23460207, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study provides evidence that DNA-binding components of the budding yeast Shu complex, Csm2-Psy3, bind double-flap DNA substrates containing an abasic site analog, and increase chromatin association when abasic sites accumulate. Importantly, Csm2-Psy3 blocks AP endonuclease cleavage at a double-flap DNA substrate, thus preventing in vitro double-strand break formation.
      Title: The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway.
    2. Data indicate that Csm2, Psy3, Shu1 and Shu2 interact with each other in sequence to form a V-shape overall structure in Shu complex.
      Title: Structural basis for the functional role of the Shu complex in homologous recombination.
    3. The data suggest a model in which Csm2-Psy3 recruit the Shu complex to homologous recombination substrates, where it interacts with Rad51 through Rad55-Rad57 to stimulate Rad51 filament assembly and stability, promoting error-free repair.
      Title: The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.
    4. analysis of the crystal structure of the Psy3-Csm2 sub-complex
      Title: Structural and SAXS analysis of the budding yeast SHU-complex proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombinase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of rDNA IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in recombinational repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in recombinational repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in recombinational repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Shu complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Shu complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Shu complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in site of double-strand break IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Csm2p
    NP_012134.1
    • Subunit of the Shu complex (aka PCSS complex); Shu complex also includes Psy3, Shu1, Shu2, and promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p anti-recombinase function; promotes formation of Rad51p filaments; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      99860..100501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179480.1 → NP_012134.1  TPA: Csm2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012134.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVF5, P40465, Q45U15
      UniProtKB/TrEMBL
      C7GUP9
      Conserved Domains (1) summary
      cd19478
      Location:7 → 212
      Csm2; Shu complex subunit Csm2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40465.1

    Gene LinkOut

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