RPL40A ubiquitin-ribosomal 60S subunit protein L40A fusion protein [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPL40A
Official Full Name: ubiquitin-ribosomal 60S subunit protein L40A fusion protein
Primary source: SGD:S000001410
Locus tag: YIL148W
See related: AllianceGenome:SGD:S000001410; FungiDB:YIL148W; VEuPathDB:YIL148W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CEP52A; UB11; UBI1
Summary: Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Involved in protein ubiquitination; ribosomal large subunit assembly; and ribosomal large subunit export from nucleus. Located in cytoplasm and nucleus. Part of cytosolic large ribosomal subunit. Orthologous to human UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPL40A in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 2

Sequence:: Chromosome: IX; NC_001141.2 (68708..69528)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicte that the deletion of either RPL40A or RPL40B results in a mild growth defect.
Title: Yeast ribosomal protein L40 assembles late into precursor 60 S ribosomes and is required for their cytoplasmic maturation.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tag activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables structural constituent of ribosome	IC Inferred by Curator more info	PubMed
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in modification-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin-ribosomal 60S subunit protein L40A fusion protein

NP_012118.1

Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

68708..69528

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179496.1 → NP_012118.1 TPA: ubiquitin-ribosomal 60S subunit protein L40A fusion protein [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012118.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVD9, P0CH08, P0CH09, P14796, P61864, Q6LA96

UniProtKB/TrEMBL

A6ZVC8, B3LRG8, C8ZAW5, G2WG04, N1P2T8

Conserved Domains (2) summary

cd01803
Location:1 → 76

Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

pfam01020
Location:79 → 126

Ribosomal_L40e; Ribosomal L40e family