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    UBP7 ubiquitin-specific protease UBP7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UBP7
    Official Full Name
    ubiquitin-specific protease UBP7
    Primary source
    SGD:S000001418
    Locus tag
    YIL156W
    See related
    AllianceGenome:SGD:S000001418; FungiDB:YIL156W; VEuPathDB:YIL156W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 6. Orthologous to human USP26 (ubiquitin specific peptidase 26) and USP29 (ubiquitin specific peptidase 29). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See UBP7 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (48091..51306)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Coa1p Neighboring gene mitofissin Neighboring gene glycerol-3-phosphate dehydrogenase Neighboring gene Imp21p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative Proteomics-Based Substrate Screening Revealed Cyclophilin Stabilization Regulated by Deubiquitinase Ubp7. Wang Y, et al. J Proteome Res, 2023 Jul 7. PMID 37341107
    2. Small toxic protein encoded on chromosome VII of Saccharomyces cerevisiae. Makanae K, et al. PLoS One, 2015. PMID 25781884, Free PMC Article
    3. Regulation of clathrin-mediated endocytosis by dynamic ubiquitination and deubiquitination. Weinberg JS, et al. Curr Biol, 2014 May 5. PMID 24746795, Free PMC Article
    4. Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies. Ren J, et al. Mol Biol Cell, 2007 Jan. PMID 17079730, Free PMC Article
    5. Analysis of an inactivated Lg-FLO1 gene present in bottom-fermenting yeast. Sato M, et al. J Biosci Bioeng, 2002. PMID 16233220

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Quantitative Proteomics-Based Substrate Screening Revealed Cyclophilin Stabilization Regulated by Deubiquitinase Ubp7.
      Title: Quantitative Proteomics-Based Substrate Screening Revealed Cyclophilin Stabilization Regulated by Deubiquitinase Ubp7.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-specific protease UBP7
    NP_012110.1
    • Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; involved in cell cycle progression through S phase; UBP7 has a paralog, UBP11, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      48091..51306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179504.1 → NP_012110.1  TPA: ubiquitin-specific protease UBP7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVD1, P40453
      UniProtKB/TrEMBL
      G2WFZ6, N1P451
      Conserved Domains (2) summary
      smart00450
      Location:328 → 443
      RHOD; Rhodanese Homology Domain
      pfam00443
      Location:609 → 1066
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40453.1

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