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    COA1 Coa1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COA1
    Official Full Name
    Coa1p
    Primary source
    SGD:S000001419
    Locus tag
    YIL157C
    See related
    AllianceGenome:SGD:S000001419; FungiDB:YIL157C; VEuPathDB:YIL157C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COA1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (46949..47542, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene formin BNR1 Neighboring gene Aim20p Neighboring gene mitofissin Neighboring gene ubiquitin-specific protease UBP7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast. Reinhold R, et al. Hum Mol Genet, 2011 Jun 15. PMID 21470975
    2. Stabilization of Cox1p intermediates by the Cox14p-Coa3p complex. McStay GP, et al. FEBS Lett, 2013 Apr 2. PMID 23434581, Free PMC Article
    3. Modular assembly of yeast cytochrome oxidase. McStay GP, et al. Mol Biol Cell, 2013 Feb. PMID 23266989, Free PMC Article
    4. Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1. Pierrel F, et al. Mol Cell Biol, 2008 Aug. PMID 18541668, Free PMC Article
    5. The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10. Bestwick M, et al. Mol Cell Biol, 2010 Jan. PMID 19841065, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assemb
      Title: Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial cytochrome c oxidase assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Coa1p
    NP_012109.1
    • Mitochondrial inner membrane protein; required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      46949..47542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179505.1 → NP_012109.1  TPA: Coa1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVC9, P40452
      UniProtKB/TrEMBL
      A6ZVB9, B3LU05, C7GUS3, C8ZAV5, G2WFZ4, N1P944
      Conserved Domains (1) summary
      pfam08695
      Location:74 → 189
      Coa1; Cytochrome oxidase complex assembly protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40452.1

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