RRN7 Rrn7p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RRN7
Official Full Name: Rrn7p
Primary source: SGD:S000003562
Locus tag: YJL025W
See related: AllianceGenome:SGD:S000003562; FungiDB:YJL025W; VEuPathDB:YJL025W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables RNA polymerase I core promoter sequence-specific DNA binding activity and TBP-class protein binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Located in nucleolus. Part of RNA polymerase I core factor complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RRN7 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (393967..395511)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Core Factor's intrinsic mobility correlates well with different conformational states of the Pol I cleft, in addition to the stabilization of either Rrn7 N-terminal domain near Pol I wall or the tandem winged helix domain of A49 at a partially overlapping location.
Title: Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
findings show that Rrn7, a subunit of the yeast Pol I core factor, and its human ortholog TAF1B are TFIIB-like factors
Title: Yeast Rrn7 and human TAF1B are TFIIB-related RNA polymerase I general transcription factors.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase I core promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase I core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase I core promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables TBP-class protein binding	IDA Inferred from Direct Assay more info	PubMed
enables TBP-class protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA polymerase I preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in nucleolar large rRNA transcription by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleolar large rRNA transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleolar large rRNA transcription by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase I	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase I core factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase I core factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase I core factor complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase I transcription regulator complex	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rrn7p

NP_012509.1

Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

393967..395511

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181459.1 → NP_012509.1 TPA: Rrn7p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012509.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWF7, P40992

UniProtKB/TrEMBL

A6ZPU9, B3LQ84, C7GSQ0, G2WGZ1, N1P8K0

Conserved Domains (2) summary

pfam11781
Location:4 → 37

zf-RRN7; Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7

cl15755
Location:363 → 399

SAM_superfamily; SAM (Sterile alpha motif )