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    BET3 TRAPP complex core subunit BET3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853942, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BET3
    Official Full Name
    TRAPP complex core subunit BET3
    Primary source
    SGD:S000001776
    Locus tag
    YKR068C
    See related
    AllianceGenome:SGD:S000001776; FungiDB:YKR068C; VEuPathDB:YKR068C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including Golgi vesicle transport; cellular response to nitrogen starvation; and cytoplasm to vacuole targeting by the Cvt pathway. Located in cis-Golgi network membrane. Part of TRAPPI protein complex; TRAPPII protein complex; and TRAPPIII protein complex. Orthologous to several human genes including TRAPPC3 (trafficking protein particle complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BET3 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (570328..570909, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene cytochrome-c peroxidase Neighboring gene bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 Neighboring gene uroporphyrinogen-III C-methyltransferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A trs20 mutation that mimics an SEDT-causing mutation blocks selective and non-selective autophagy: a model for TRAPP III organization. Brunet S, et al. Traffic, 2013 Oct. PMID 23898804
    2. TRAPPI tethers COPII vesicles by binding the coat subunit Sec23. Cai H, et al. Nature, 2007 Feb 22. PMID 17287728
    3. Trs33-Containing TRAPP IV: A Novel Autophagy-Specific Ypt1 GEF. Lipatova Z, et al. Genetics, 2016 Nov. PMID 27672095, Free PMC Article
    4. TRAPP stimulates guanine nucleotide exchange on Ypt1p. Wang W, et al. J Cell Biol, 2000 Oct 16. PMID 11038176, Free PMC Article
    5. The TRAPP complex is a nucleotide exchanger for Ypt1 and Ypt31/32. Jones S, et al. Mol Biol Cell, 2000 Dec. PMID 11102533, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bet3 is involved in autophagy and participates in autophagy through TRAPP complexes mostly via Ypt1 in yeast.
      Title: Bet3 participates in autophagy through GTPase Ypt1 in Saccharomyces cerevisiae.
    2. Incorporated into the transport protein particle by Trs33.
      Title: Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to nitrogen starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPPI protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPIII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cis-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cis-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TRAPP complex core subunit BET3
    NP_012994.1
    • Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); hydrophilic homodimeric protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      570328..570909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179858.1 → NP_012994.1  TPA: TRAPP complex core subunit BET3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXC9, P36149
      UniProtKB/TrEMBL
      A7A028, B3LRE3, B5VML5, C7GX71, C8ZCN0, G2WI96, N1P0J3
      Conserved Domains (1) summary
      cd14942
      Location:26 → 182
      TRAPPC3_bet3; Bet3-TRAPPC3 subunit of the TRAPP complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36149.1

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