MEC3 Mec3p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MEC3
Official Full Name: Mec3p
Primary source: SGD:S000004279
Locus tag: YLR288C
See related: AllianceGenome:SGD:S000004279; FungiDB:YLR288C; VEuPathDB:YLR288C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PIP3; PSO9
Summary: Enables DNA binding activity. Involved in DNA damage checkpoint signaling; subtelomeric heterochromatin formation; and telomere maintenance via recombination. Part of checkpoint clamp complex. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

a Ddc1-Mec3-Rad17 sliding clamp has a role in regulating histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast
Title: The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast.
Control of telomeric recombination by Mec3.
Title: Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA.
Overexpression of MEC3 in a DDC1Delta strain shows no rescue of DNA damage sensitivity.
Title: Function of Rad17/Mec3/Ddc1 and its partial complexes in the DNA damage checkpoint.
a mutant allele of the DNA damage checkpoint gene MEC3 is in Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae
Title: Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae contains a mutant allele of the DNA damage checkpoint gene MEC3.
the 9-1-1 clamp, made of Ddc1, Rad17, and Mec3, may physically regulate Polzeta-dependent mutagenesis by controlling the access of Polzeta to damaged DNA
Title: The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic DNA integrity checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in subtelomeric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via recombination	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of checkpoint clamp complex	IBA Inferred from Biological aspect of Ancestor more info
part_of checkpoint clamp complex	IDA Inferred from Direct Assay more info	PubMed
part_of checkpoint clamp complex	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info

NP_013391.1

DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1