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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854990, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000004480
    Locus tag
    YML018C
    See related
    AllianceGenome:SGD:S000004480; FungiDB:YML018C; VEuPathDB:YML018C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in fungal-type vacuole membrane. Orthologous to human SLC35F5 (solute carrier family 35 member F5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (234771..235952, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase Neighboring gene Psp2p Neighboring gene salt homeostasis regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YML018C protein localizes to the vacuolar membrane independently of Atg27p. Sturgeon CM, et al. MicroPubl Biol, 2021 May 12. PMID 33997660, Free PMC Article
    2. The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat. Shortill SP, et al. Elife, 2022 Aug 8. PMID 35938928, Free PMC Article
    3. Regulation of septin dynamics by the Saccharomyces cerevisiae lysine acetyltransferase NuA4. Mitchell L, et al. PLoS One, 2011. PMID 21984913, Free PMC Article
    4. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII. Bowman S, et al. Nature, 1997 May 29. PMID 9169872
    5. Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Tkach JM, et al. Nat Cell Biol, 2012 Sep. PMID 22842922, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_013694.1
    • hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      234771..235952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182376.1 → NP_013694.1  TPA: uncharacterized protein YML018C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013694.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZF6, Q03730, Q6B2K7
      UniProtKB/TrEMBL
      A6ZM44, G2WK34, N1NX37
      Conserved Domains (1) summary
      COG0697
      Location:142 → 367
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03730.1

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