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    RPC19 DNA-directed RNA polymerase core subunit RPC19 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPC19
    Official Full Name
    DNA-directed RNA polymerase core subunit RPC19
    Primary source
    SGD:S000005057
    Locus tag
    YNL113W
    See related
    AllianceGenome:SGD:S000005057; FungiDB:YNL113W; VEuPathDB:YNL113W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA polymerase I activity and RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III and transcription by RNA polymerase I. Part of RNA polymerase I complex and RNA polymerase III complex. Used to study Treacher Collins syndrome 2 and leukodystrophy. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 2. Orthologous to human POLR1D (RNA polymerase I and III subunit D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPC19 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (412771..413199)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating protein DMA2 Neighboring gene uncharacterized protein Neighboring gene DEAD-box ATP-dependent RNA helicase DBP2 Neighboring gene Cyb5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RPC19, the gene for a subunit common to yeast RNA polymerases A (I) and C (III). Dequard-Chablat M, et al. J Biol Chem, 1991 Aug 15. PMID 1869554
    2. Reconstitution of yeast and Arabidopsis RNA polymerase alpha-like subunit heterodimers. Larkin RM, et al. J Biol Chem, 1997 May 9. PMID 9139743
    3. Treacher Collins syndrome mutations in Saccharomyces cerevisiae destabilize RNA polymerase I and III complex integrity. Walker-Kopp N, et al. Hum Mol Genet, 2017 Nov 1. PMID 28973381, Free PMC Article
    4. Rpc19 and Rpc40, two alpha-like subunits shared by nuclear RNA polymerases I and III, are interchangeable between the fission and budding yeasts. Shpakovski GV, et al. Curr Genet, 1999 Oct. PMID 10541858
    5. The fission yeast rpa17+ gene encodes a functional homolog of AC19, a subunit of RNA polymerases I and III of Saccharomyces cerevisiae. Imai K, et al. Mol Gen Genet, 1999 Mar. PMID 10102372

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase I activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase core subunit RPC19
    NP_014286.1
    • RNA polymerase subunit AC19; common to RNA polymerases I and III

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      412771..413199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182951.1 → NP_014286.1  TPA: DNA-directed RNA polymerase core subunit RPC19 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014286.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W168, P28000
      UniProtKB/TrEMBL
      A6ZRW9, B3LNX1, C7GKD1, C8ZGB7, G2WLZ3, N1NWJ5
      Conserved Domains (1) summary
      cd07029
      Location:52 → 135
      RNAP_I_III_AC19; AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28000.1

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