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    KRE33 ribosome biosynthesis protein KRE33 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855591, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KRE33
    Official Full Name
    ribosome biosynthesis protein KRE33
    Primary source
    SGD:S000005076
    Locus tag
    YNL132W
    See related
    AllianceGenome:SGD:S000005076; FungiDB:YNL132W; VEuPathDB:YNL132W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RRA1
    Summary
    Enables rRNA cytidine N-acetyltransferase activity; snoRNA binding activity; and tRNA binding activity. Involved in mRNA modification and ribosomal small subunit biogenesis. Located in nucleolus. Part of 90S preribosome. Orthologous to human NAT10 (N-acetyltransferase 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KRE33 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (375321..378491)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Fyv6p Neighboring gene tRNA-Phe Neighboring gene Tom22p Neighboring gene diacylglycerol cholinephosphotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A single acetylation of 18 S rRNA is essential for biogenesis of the small ribosomal subunit in Saccharomyces cerevisiae. Ito S, et al. J Biol Chem, 2014 Sep 19. PMID 25086048, Free PMC Article
    2. Identification and Quantification of Modified Nucleosides in Saccharomyces cerevisiae mRNAs. Tardu M, et al. ACS Chem Biol, 2019 Jul 19. PMID 31243956, Free PMC Article
    3. Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration. Cheng J, et al. Mol Cell, 2019 Sep 19. PMID 31378463
    4. Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Sas-Chen A, et al. Nature, 2020 Jul. PMID 32555463, Free PMC Article
    5. Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1. Sharma S, et al. Nucleic Acids Res, 2015 Feb 27. PMID 25653167, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Kre33 as responsible for both 18S rRNA and leucine/serine tRNA acetylation.
      Title: Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1.
    2. KRE3 (Rra1p) modulates biogenesis of the 40 S subunit by sensing nuclear acetyl-CoA concentration.
      Title: A single acetylation of 18 S rRNA is essential for biogenesis of the small ribosomal subunit in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA cytidine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA cytidine N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA acetylation involved in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA acetylation involved in maturation of SSU-rRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble cytosine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosome biosynthesis protein KRE33
    NP_014267.1
    • Acetyltransferase required for biogenesis of small ribosomal subunit; conserved 18S rRNA cytosine acetyltransferase that modifies tRNAs assisted by adaptor Tan1p; responsible for incorporation of N4-acetylcytidine into mRNAs; human homolog NAT10 implicated in several types of cancer and premature aging

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      375321..378491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182970.1 → NP_014267.1  TPA: ribosome biosynthesis protein KRE33 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014267.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W150, P53914
      UniProtKB/TrEMBL
      A6ZRV1, B5VQR6, C7GKB4, C8ZG98, G2WLX4, N1P4B1
      Conserved Domains (1) summary
      COG1444
      Location:20 → 930
      TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53914.1

    Gene LinkOut

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