MSB3 Rab GTPase-activating protein MSB3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MSB3
Official Full Name: Rab GTPase-activating protein MSB3
Primary source: SGD:S000005237
Locus tag: YNL293W
See related: AllianceGenome:SGD:S000005237; FungiDB:YNL293W; VEuPathDB:YNL293W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GYP3
Summary: Enables GTPase activator activity. Involved in several processes, including endocytosis; exocytosis; and formin-nucleated actin cable assembly. Located in several cellular components, including cellular bud tip; fungal-type vacuole membrane; and incipient cellular bud site. Part of polarisome. Used to study Ewing sarcoma and cancer. Orthologous to human GRTP1 (growth hormone regulated TBC protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

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BLOC-1 is both a Vps21 effector and an adapter for its GAP Msb3.
Title: The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3.
Gyp3 spatially restricts active Vps21 to intermediate endosomes.
Title: Termination of isoform-selective Vps21/Rab5 signaling at endolysosomal organelles by Msb3/Gyp3.
Msb3 can act on multiple substrates in vivo at both ends of a trafficking pathway
Title: The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles.
The results suggest a possible involvement of Msb3p in calcineurin-mediated signalling.
Title: Multicopy suppression screen in a Saccharomyces cerevisiae strain lacking the Rab GTPase-activating protein Msb3p.
Msb3 and Msb4 interact with Cdc42 and polarisome components to regulate cell polarity
Title: Regulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IPI Inferred from Physical Interaction more info	PubMed
involved_in exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in formin-nucleated actin cable assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in formin-nucleated actin cable assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cellular bud	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck	HDA more info	PubMed
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
located_in cellular bud tip	HDA more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of polarisome	IDA Inferred from Direct Assay more info	PubMed
located_in site of polarized growth	IEA Inferred from Electronic Annotation more info

NP_014106.1

Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; localizes to plasma membrane, sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null

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