ADH1 alcohol dehydrogenase ADH1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ADH1
Official Full Name: alcohol dehydrogenase ADH1
Primary source: SGD:S000005446
Locus tag: YOL086C
See related: AllianceGenome:SGD:S000005446; FungiDB:YOL086C; VEuPathDB:YOL086C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ADC1
Summary: Enables alcohol dehydrogenase (NAD+) activity; melatonin binding activity; and methylglyoxal reductase (NADH) activity. Involved in NADH oxidation; amino acid catabolic process to alcohol via Ehrlich pathway; and glycolytic fermentation to ethanol. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ADH1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (159548..160594, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Subunit B may represent an intermediate in the mechanism after coenzyme and alcohol bind and before the conformation changes to the closed form and the alcohol oxygen binds to the zinc and displaces Glu-67.
Title: Mechanistic implications from structures of yeast alcohol dehydrogenase complexed with coenzyme and an alcohol.
key role of Y295C mutation in HMF reduction by Adh1p.
Title: Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants.
Glucose 6-phosphate and alcohol dehydrogenase activities are components of dynamic macromolecular depot structures.
Title: Glucose 6-phosphate and alcohol dehydrogenase activities are components of dynamic macromolecular depots structures.
mutation of the ADH1 gene improves lactate production in the yeast Saccharomyces cerevisiae
Title: Double mutation of the PDC1 and ADH1 genes improves lactate production in the yeast Saccharomyces cerevisiae expressing the bovine lactate dehydrogenase gene.
a sequence -YSGVCHTDLHAWHGDWPLPVK- in the polypeptide chain possesses chaperone-like activity
Title: Mechanism of thermal aggregation of yeast alcohol dehydrogenase I: role of intramolecular chaperone.
The identification and characterization of a mutated alcohol dehydrogenase 1 from the industrial Saccharomyces cerevisiae strain TMB3000 that mediates the NADH-dependent reduction of 5-hydroxymethylfurfural (HMF) to 2,5-bis-hydroxymethylfuran.
Title: Identification of an NADH-dependent 5-hydroxymethylfurfural-reducing alcohol dehydrogenase in Saccharomyces cerevisiae.
A yeast strain with an extra copy of the ADH1 gene (2xADH1) demonstrated increased survival in stationary phase and a 30% extension in replicative life span.
Title: Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1.
During zinc deficiency, Zap1 mediates the repression of two of the most abundant zinc-requiring enzymes.
Title: Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts.
analysis of the oxidation of yeast alcohol dehydrogenase-1 by hydrogen peroxide in vitro
Title: The oxidation of yeast alcohol dehydrogenase-1 by hydrogen peroxide in vitro.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables alcohol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables allyl-alcohol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables butanol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables melatonin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylglyoxal reductase (NADH) activity	IDA Inferred from Direct Assay more info	PubMed
enables methylglyoxal reductase (NADH) activity	IEA Inferred from Electronic Annotation more info
enables octanol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in NADH oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in NADH oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid catabolic process to alcohol via Ehrlich pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glycolytic fermentation to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: alcohol dehydrogenase ADH1

NP_014555.1

EC 1.1.1.1

EC 1.1.1.54

EC 1.1.1.78

Alcohol dehydrogenase; fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; ADH1 has a paralog, ADH5, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

159548..160594 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183340.1 → NP_014555.1 TPA: alcohol dehydrogenase ADH1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014555.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1Y3, P00330

UniProtKB/TrEMBL

S5S176

Conserved Domains (1) summary

cd08297
Location:7 → 345

CAD3; Cinnamyl alcohol dehydrogenases (CAD)