NDJ1 Ndj1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NDJ1
Official Full Name: Ndj1p
Primary source: SGD:S000005464
Locus tag: YOL104C
See related: AllianceGenome:SGD:S000005464; FungiDB:YOL104C; VEuPathDB:YOL104C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TAM1
Summary: Predicted to enable telomeric DNA binding activity. Involved in meiosis I; positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric; and regulation of reciprocal meiotic recombination. Located in chromosome, telomeric region and meiotic spindle pole body. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NDJ1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (116396..117454, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we found a role for the meiotic bouquet in establishing the size dependence of centromere coupling, as abolishing bouquet (using the bouquet-defective spo11 ndj1 mutant) reduces it. Coupling in spo11 ndj1 rather follows telomere clustering preferences. We propose that a chromosome size preference for centromere coupling helps establish efficient homolog recognition.
Title: Multiple Pairwise Analysis of Non-homologous Centromere Coupling Reveals Preferential Chromosome Size-Dependent Interactions and a Role for Bouquet Formation in Establishing the Interaction Pattern.
Unlike Ndj1, Csm4 is not required for meiosis-specific telomere association.
Title: Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis.
Bouquet formation and rapid prophase movements depend on NDJ1, MPS3, and a new member of this pathway, CSM4, which encodes a meiosis-specific nuclear envelope protein required specifically for telomere mobility.
Title: Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination.
Ndj1p facilitates deletion (telomere-length shortening) by promoting telomeric interactions during meiosis, resulting in an effective increase in the concentration of limiting factors for deletion.
Title: Ndj1p-dependent epigenetic resetting of telomere size in yeast meiosis.
Ndj1 promotes meiotic rcombination.
Title: Ndj1, a telomere-associated protein, promotes meiotic recombination in budding yeast.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables telomeric DNA binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in homologous chromosome pairing at meiosis	IDA Inferred from Direct Assay more info	PubMed
involved_in homologous chromosome pairing at meiosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic attachment of telomere to nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic telomere clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in meiotic telomere clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in meiotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ndj1p

NP_014537.1

Protein that regulates meiotic SPB cohesion and telomere clustering; localizes to both spindle pole bodies (SPBs) and telomeres; required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement