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    HEM15 ferrochelatase HEM15 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854347, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HEM15
    Official Full Name
    ferrochelatase HEM15
    Primary source
    SGD:S000005702
    Locus tag
    YOR176W
    See related
    AllianceGenome:SGD:S000005702; FungiDB:YOR176W; VEuPathDB:YOR176W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ferrochelatase activity. Involved in heme biosynthetic process. Located in mitochondrion. Is active in mitochondrial inner membrane. Used to study cancer. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HEM15 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (662401..663582)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Med4p Neighboring gene lysophospholipid acyltransferase Neighboring gene tRNA-Val Neighboring gene Mpc54p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and functional characterization of mutant ferrochelatases in Saccharomyces cerevisiae. Góra M, et al. Biochimie, 1996. PMID 8818224
    2. Examination of the activity of carboxyl-terminal chimeric constructs of human and yeast ferrochelatases. Medlock AE, et al. Biochemistry, 2000 Jun 27. PMID 10858295
    3. Yeast ferrochelatase: expression in a baculovirus system and purification of the expression protein. Eldridge MG, et al. Protein Sci, 1992 Feb. PMID 1304908, Free PMC Article
    4. The ferrochelatase from Saccharomyces cerevisiae. Sequence, disruption, and expression of its structural gene HEM15. Labbe-Bois R. J Biol Chem, 1990 May 5. PMID 2185242
    5. Purification and properties of ferrochelatase from the yeast Saccharomyces cerevisiae. Evidence for a precursor form of the protein. Camadro JM, et al. J Biol Chem, 1988 Aug 25. PMID 3042776

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ferrochelatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrochelatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferrochelatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrochelatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ferrochelatase HEM15
    NP_014819.3
    • Ferrochelatase; a mitochondrial inner membrane protein, catalyzes insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; human homolog FECH can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      662401..663582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183595.3 → NP_014819.3  TPA: ferrochelatase HEM15 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014819.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2N2, P16622
      UniProtKB/TrEMBL
      A7A2C1, B3LJK6, C7GN51, C8ZGT7, G2WN49, N1NYK0
      Conserved Domains (1) summary
      TIGR00109
      Location:34 → 358
      hemH; ferrochelatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16622.1

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