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    MPC54 Mpc54p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854349, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MPC54
    Official Full Name
    Mpc54p
    Primary source
    SGD:S000005703
    Locus tag
    YOR177C
    See related
    AllianceGenome:SGD:S000005703; FungiDB:YOR177C; VEuPathDB:YOR177C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables structural molecule activity. Involved in ascospore-type prospore membrane formation and vesicle docking. Located in meiotic spindle pole body. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MPC54 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (665785..667179, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ferrochelatase HEM15 Neighboring gene tRNA-Val Neighboring gene protein phosphatase regulator GAC1 Neighboring gene cleavage polyadenylation factor subunit SYC1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ADY1, a novel gene required for prospore membrane formation at selected spindle poles in Saccharomyces cerevisiae. Deng C, et al. Mol Biol Cell, 2001 Sep. PMID 11553705, Free PMC Article
    2. Spore number control and breeding in Saccharomyces cerevisiae: a key role for a self-organizing system. Taxis C, et al. J Cell Biol, 2005 Nov 21. PMID 16286509, Free PMC Article
    3. Vesicle docking to the spindle pole body is necessary to recruit the exocyst during membrane formation in Saccharomyces cerevisiae. Mathieson EM, et al. Mol Biol Cell, 2010 Nov 1. PMID 20826607, Free PMC Article
    4. Membrane assembly modulates the stability of the meiotic spindle-pole body. Mathieson EM, et al. J Cell Sci, 2010 Jul 15. PMID 20592185, Free PMC Article
    5. Ady4p and Spo74p are components of the meiotic spindle pole body that promote growth of the prospore membrane in Saccharomyces cerevisiae. Nickas ME, et al. Eukaryot Cell, 2003 Jun. PMID 12796288, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore-type prospore membrane formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ascospore-type prospore membrane formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in meiotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body HDA PubMed 
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mpc54p
    NP_014820.1
    • Component of the meiotic outer plaque; a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      665785..667179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183596.1 → NP_014820.1  TPA: Mpc54p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014820.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2N3, Q08550
      UniProtKB/TrEMBL
      A6ZP22, B3LJK8, C8ZGT8, N1NWQ3
      Conserved Domains (1) summary
      COG1196
      Location:135 → 364
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08550.1

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