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    CPA1 carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CPA1
    Official Full Name
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1
    Primary source
    SGD:S000005829
    Locus tag
    YOR303W
    See related
    AllianceGenome:SGD:S000005829; FungiDB:YOR303W; VEuPathDB:YOR303W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity. Involved in L-arginine biosynthetic process. Located in cytoplasmic stress granule. Part of carbamoyl-phosphate synthase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CPA1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (882899..884134)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rax1p Neighboring gene uncharacterized protein Neighboring gene DNA translocase Neighboring gene Bil1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of yeast gene CP A1 encoding the small subunit of arginine-pathway carbamoyl-phosphate synthetase. Homology of the deduced amino acid sequence to other glutamine amidotransferases. Werner M, et al. Eur J Biochem, 1985 Jan 15. PMID 3881260
    2. Evolutionarily conserved features of the arginine attenuator peptide provide the necessary requirements for its function in translational regulation. Fang P, et al. J Biol Chem, 2000 Sep 1. PMID 10818103
    3. The leader peptide of yeast gene CPA1 is essential for the translational repression of its expression. Werner M, et al. Cell, 1987 Jun 19. PMID 3555844
    4. The biosynthesis of carbamoyl phosphate in Saccharomyces cerevisiae. Lacroute F, et al. J Gen Microbiol, 1965 Jul. PMID 5856369
    5. In vivo mutational analysis of highly conserved amino acid residues of the small subunit Cpa1p of the carbamylphosphate synthetase of Saccharomyces cerevisiae. Bernard A, et al. Yeast, 1997 Sep 15. PMID 9290206

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-arginine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-arginine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of carbamoyl-phosphate synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of carbamoyl-phosphate synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 

    General protein information

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    Preferred Names
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1
    NP_014947.3
    • Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      882899..884134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183722.3 → NP_014947.3  TPA: carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014947.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W302, P07258
      UniProtKB/TrEMBL
      A6ZPD8, C7GNV8, C8ZH53, G2WNG9, N1NWY7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07258.1

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