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    NOG1 putative GTPase NOG1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856012, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NOG1
    Official Full Name
    putative GTPase NOG1
    Primary source
    SGD:S000006014
    Locus tag
    YPL093W
    See related
    AllianceGenome:SGD:S000006014; FungiDB:YPL093W; VEuPathDB:YPL093W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and RNA binding activity. Involved in assembly of large subunit precursor of preribosome; rRNA processing; and ribosomal subunit export from nucleus. Located in cytoplasm and nucleolus. Part of preribosome, large subunit precursor. Orthologous to human GTPBP4 (GTP binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NOG1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (370978..372921)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene medium-chain fatty acid ethyl ester synthase/esterase Neighboring gene Sec63 complex subunit SEC62 Neighboring gene Ssu1p Neighboring gene glutathione-disulfide reductase GLR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel nucleolar G-protein conserved in eukaryotes. Park JH, et al. J Cell Sci, 2001 Jan. PMID 11112701
    2. Essential role of NbNOG1 in ribosomal RNA processing. Guo J, et al. J Integr Plant Biol, 2018 Nov. PMID 30252198
    3. A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits. Nissan TA, et al. Mol Cell, 2004 Jul 23. PMID 15260980
    4. Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products. Defenouillère Q, et al. Proc Natl Acad Sci U S A, 2013 Mar 26. PMID 23479637, Free PMC Article
    5. Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1. Pertschy B, et al. Mol Cell Biol, 2007 Oct. PMID 17646390, Free PMC Article

    See all (173) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers.
      Title: The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers.
    2. Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel.
      Title: Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel.
    3. analysis of the Saccharomyces cerevisiae 60S biogenesis GTPase Nog1
      Title: In vivo functional characterization of the Saccharomyces cerevisiae 60S biogenesis GTPase Nog1.
    4. Nog1 complex is a critical regulator of ribosome biogenesis mediated by TOR.
      Title: TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in assembly of large subunit precursor of preribosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative GTPase NOG1
    NP_015232.1
    • Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      370978..372921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183907.1 → NP_015232.1  TPA: putative GTPase NOG1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015232.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3S4, Q02892
      UniProtKB/TrEMBL
      A6ZWF8, B3LKY0, C7GJ47, C8ZIT7, G2WP88, N1P1L8
      Conserved Domains (2) summary
      COG1084
      Location:1 → 346
      Nog1; GTP-binding protein, GTP1/Obg family [General function prediction only]
      pfam08155
      Location:399 → 449
      NOGCT; NOGCT (NUC087) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02892.1

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