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    MDM36 Mdm36p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MDM36
    Official Full Name
    Mdm36p
    Primary source
    SGD:S000006287
    Locus tag
    YPR083W
    See related
    AllianceGenome:SGD:S000006287; FungiDB:YPR083W; VEuPathDB:YPR083W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial fission and mitochondrion inheritance. Acts upstream of or within intracellular distribution of mitochondria. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MDM36 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (704854..706593)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative glycine--tRNA ligase Neighboring gene U4/U6-U5 snRNP complex subunit DIB1 Neighboring gene uncharacterized protein Neighboring gene Asa1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical Characterization of the Num1-Mdm36 Complex at the Mitochondria-Plasma Membrane Contact Site. Won J, et al. Mol Cells, 2021 Apr 30. PMID 33827993, Free PMC Article
    2. Num1 anchors mitochondria to the plasma membrane via two domains with different lipid binding specificities. Ping HA, et al. J Cell Biol, 2016 Jun 6. PMID 27241910, Free PMC Article
    3. Endoplasmic reticulum-associated mitochondria-cortex tether functions in the distribution and inheritance of mitochondria. Lackner LL, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341591, Free PMC Article
    4. Overexpression of Mdm36 reveals Num1 foci that mediate dynein-dependent microtubule sliding in budding yeast. Omer S, et al. J Cell Sci, 2020 Oct 15. PMID 32938686, Free PMC Article
    5. The yeast cell cortical protein Num1 integrates mitochondrial dynamics into cellular architecture. Klecker T, et al. J Cell Sci, 2013 Jul 1. PMID 23641071

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biochemical Characterization of the Num1-Mdm36 Complex at the Mitochondria-Plasma Membrane Contact Site.
      Title: Biochemical Characterization of the Num1-Mdm36 Complex at the Mitochondria-Plasma Membrane Contact Site.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular distribution of mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mdm36p
    NP_015408.1
    • Mitochondrial protein; required for normal mitochondrial morphology and inheritance; component of the mitochondria-ER-cortex-anchor (MECA); interacts with Num1p to link the ER and mitochondria at the cell cortex; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      704854..706593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184180.1 → NP_015408.1  TPA: Mdm36p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015408.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W485, Q06820
      UniProtKB/TrEMBL
      A6ZWW8, B3LK53, C7GPS6, C8ZJA8, N1NVK6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06820.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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