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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850876, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000004169
    Locus tag
    YLR179C
    See related
    AllianceGenome:SGD:S000004169; FungiDB:YLR179C; VEuPathDB:YLR179C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable peptidase inhibitor activity and phospholipid binding activity. Predicted to be involved in regulation of Ras protein signal transduction and regulation of proteolysis. Located in cytoplasm. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PEBP1 (phosphatidylethanolamine binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (514108..514713, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tfs1p Neighboring gene methionine adenosyltransferase SAM1 Neighboring gene Vta1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical analysis of the yeast proteinase inhibitor (IC) homolog ICh and its comparison with IC. Fukada H, et al. Biosci Biotechnol Biochem, 2007 Feb. PMID 17317927
    2. Molecular basis of the Tfs1/Ira2 interaction: a combined protein engineering and molecular modelling study. Gombault A, et al. J Mol Biol, 2007 Nov 30. PMID 17945254
    3. Tfs1p, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase-activating protein in Saccharomyces cerevisiae. Chautard H, et al. Eukaryot Cell, 2004 Apr. PMID 15075275, Free PMC Article
    4. Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. Lucau-Danila A, et al. J Biol Chem, 2003 Dec 26. PMID 14512416
    5. Analysis of the vacuolar luminal proteome of Saccharomyces cerevisiae. Sarry JE, et al. FEBS J, 2007 Aug. PMID 17651441

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_013280.1
    • hypothetical protein with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      514108..514713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182066.1 → NP_013280.1  TPA: uncharacterized protein YLR179C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013280.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYI3, Q06252
      UniProtKB/TrEMBL
      A7A170, G2WJ12, N1NZD3
      Conserved Domains (1) summary
      cd00866
      Location:30 → 190
      PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06252.1

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