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    LINC01876 long intergenic non-protein coding RNA 1876 [ Homo sapiens (human) ]

    Gene ID: 101929378, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC01876provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1876provided by HGNC
    Primary source
    HGNC:HGNC:52695
    See related
    Ensembl:ENSG00000226383 AllianceGenome:HGNC:52695
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    uc.83
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See LINC01876 in Genome Data Viewer
    Location:
    2q24.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (156020535..156254931, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (156473177..156707586, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (156877047..157111443, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985828 Neighboring gene uncharacterized LOC105373703 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:156697781-156698549 Neighboring gene VISTA enhancer hs411 Neighboring gene MPRA-validated peak3904 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:156903772-156904272 Neighboring gene MPRA-validated peak3905 silencer Neighboring gene MPRA-validated peak3906 silencer Neighboring gene HEBP2 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:156939984-156941183 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:157031916-157032139 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53336 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:157149084-157149974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16659 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:157190964-157191836 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:157197537-157198092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:157198093-157198646 Neighboring gene uncharacterized LOC440918 Neighboring gene nuclear receptor subfamily 4 group A member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification. Garza R, et al. Sci Adv, 2023 Nov 3. PMID 37910626, Free PMC Article
    2. Overexpression of ultraconserved region 83- induces lung cancer tumorigenesis. Vannini I, et al. PLoS One, 2022. PMID 35015757, Free PMC Article
    3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • ultraconserved element 83

    Clone Names

    • AC093375.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_110249.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate splice sites in an internal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC073551, AC074099, AC093375, BC032407, DB016766
      Related
      ENST00000428651.2

    2. NR_110250.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC073551, AC074099, AC093375, BC032407, CN272405, DB016766
      Related
      ENST00000662073.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      156020535..156254931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      156473177..156707586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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