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    KCNMB2-AS1 KCNMB2 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 104797538, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KCNMB2-AS1provided by HGNC
    Official Full Name
    KCNMB2 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:51409
    See related
    AllianceGenome:HGNC:51409
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See KCNMB2-AS1 in Genome Data Viewer
    Location:
    3q26.32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (178525467..178860405, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (181328698..181664243, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (178243255..178578193, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1014 Neighboring gene RNA, 5S ribosomal pseudogene 148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20852 Neighboring gene peptidylprolyl isomerase A pseudogene 75 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14907 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20855 Neighboring gene MPRA-validated peak4947 silencer Neighboring gene uncharacterized LOC124909461 Neighboring gene NANOG hESC enhancer GRCh37_chr3:178545086-178545618 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:178578153-178578979 Neighboring gene uncharacterized LOC124906307 Neighboring gene MPRA-validated peak4949 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14909 Neighboring gene zinc finger matrin-type 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Long noncoding RNA KCNMB2-AS1 acts as an oncogene in ovarian cancer. Cao S, et al. Acta Biochim Biophys Sin (Shanghai), 2023 Nov 25. PMID 37710992, Free PMC Article
    2. Detection of long-chain non-encoding RNA differential expression in non-small cell lung cancer by microarray analysis and preliminary verification. Wang Y, et al. Mol Med Rep, 2015 Mar. PMID 25394782
    3. Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis. Xu J, et al. Bioengineered, 2021 Dec. PMID 34516362, Free PMC Article
    4. Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes. Speek M. Mol Cell Biol, 2001 Mar. PMID 11238933, Free PMC Article
    5. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long noncoding RNA KCNMB2-AS1 acts as an oncogene in ovarian cancer.
      Title: Long noncoding RNA KCNMB2-AS1 acts as an oncogene in ovarian cancer.
    2. Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis.
      Title: Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • RP11-385J1.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_126560.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC024220, AC117457

    2. NR_126561.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three exons, contains an alternate exon, and uses an alternate splice site at an internal exon, resulting in a shorter transcript than variant 1.
      Source sequence(s)
      AC024220, AC117457

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      178525467..178860405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      181328698..181664243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials