STKLD1 serine/threonine kinase like domain containing 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STKLD1provided by HGNC
Official Full Name: serine/threonine kinase like domain containing 1provided by HGNC
Primary source: HGNC:HGNC:28669
See related: Ensembl:ENSG00000198870 MIM:618530; AllianceGenome:HGNC:28669
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Sk521; SgK071; C9orf96
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis (RPKM 4.5), brain (RPKM 0.4) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q34.2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (133376366..133406096)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (145590326..145620528)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (136243237..136271220)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Also known as SgK071, a unique kinase belonging to no group or family. Single orthologs have been found in other vertebrates and lower metazoans including Nematostella, but are absent from Drosophila and C. elegans.
Title: The protein kinase complement of the human genome.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9S164 (e-PCR), detects polymorphism
- UniSTS:38925

A008L29 (e-PCR)
- UniSTS:6160

D14S594 (e-PCR)
- UniSTS:30246

D9S164 (e-PCR), detects polymorphism
- UniSTS:36197

RH75089 (e-PCR)
- UniSTS:92284

WI-21963 (e-PCR)
- UniSTS:31895

Cda18h02 (e-PCR)
- UniSTS:88740

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine kinase-like domain-containing protein STKLD1

Names: probable inactive protein kinase-like protein SgK071; serine/threonine kinase-like domain-containing protein 1; sugen kinase 071

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153710.5 → NP_714921.4 serine/threonine kinase-like domain-containing protein STKLD1

See identical proteins and their annotated locations for NP_714921.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the protein.

Source sequence(s)

AK131545, AL593848, BC036504

Consensus CDS

CCDS35169.1

UniProtKB/Swiss-Prot

Q5T8U8, Q6ZMP6, Q6ZMQ5, Q8NE28

Related

ENSP00000361025.3, ENST00000371957.4

Conserved Domains (1) summary

cd00180
Location:34 → 292

PKc; Catalytic domain of Protein Kinases

RNA

NR_103997.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK131545, AL593848, BC036504