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    Npl N-acetylneuraminate pyruvate lyase [ Mus musculus (house mouse) ]

    Gene ID: 74091, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nplprovided by MGI
    Official Full Name
    N-acetylneuraminate pyruvate lyaseprovided by MGI
    Primary source
    MGI:MGI:1921341
    See related
    Ensembl:ENSMUSG00000042684 AllianceGenome:MGI:1921341
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610033B02Rik
    Summary
    Enables N-acetylneuraminate lyase activity. Predicted to be involved in N-acetylneuraminate catabolic process. Predicted to be located in cytoplasm. Is expressed in early embryo; eye; and nervous system. Orthologous to human NPL (N-acetylneuraminate pyruvate lyase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 95.4), kidney adult (RPKM 16.6) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Npl in Genome Data Viewer
    Location:
    1 G3; 1 65.38 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (153378762..153425460, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (153503016..153549714, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Shc SH2-domain binding protein 1-like Neighboring gene predicted gene, 25588 Neighboring gene DExH-box helicase 9 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155334650-155334951 Neighboring gene STARR-positive B cell enhancer ABC_E7758 Neighboring gene STARR-seq mESC enhancer starr_02698 Neighboring gene STARR-seq mESC enhancer starr_02701 Neighboring gene STARR-seq mESC enhancer starr_02703 Neighboring gene STARR-seq mESC enhancer starr_02704 Neighboring gene STARR-seq mESC enhancer starr_02705 Neighboring gene predicted gene 6652 Neighboring gene regulator of G-protein signaling 8 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155538364-155538664 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155543174-155543475

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylneuraminate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables N-acetylneuraminate lyase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables N-acetylneuraminate lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in N-acetylneuraminate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in N-acetylneuraminate catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in N-acetylneuraminate catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in N-acetylneuraminate catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    N-acetylneuraminate lyase
    Names
    N-acetylneuraminic acid aldolase
    NALase
    sialate lyase
    sialate-pyruvate lyase
    sialic acid aldolase
    sialic acid lyase
    NP_083025.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028749.1NP_083025.1  N-acetylneuraminate lyase

      See identical proteins and their annotated locations for NP_083025.1

      Status: PROVISIONAL

      Source sequence(s)
      AK002734
      Consensus CDS
      CCDS15374.1
      UniProtKB/Swiss-Prot
      Q9DCJ9
      Related
      ENSMUSP00000037454.8, ENSMUST00000041874.9
      Conserved Domains (1) summary
      cl21457
      Location:8306
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      153378762..153425460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)