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    THI72 thiamine transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854364, updated on 9-Dec-2024

    Summary

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    Official Symbol
    THI72
    Official Full Name
    thiamine transporter
    Primary source
    SGD:S000005718
    Locus tag
    YOR192C
    See related
    AllianceGenome:SGD:S000005718; FungiDB:YOR192C; VEuPathDB:YOR192C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity. Involved in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport and thiamine transport. Located in cell periphery and fungal-type vacuole. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See THI72 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (698768..700567, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene glucan 1,3-beta-glucosidase Neighboring gene translocase ULS1 Neighboring gene uncharacterized protein Neighboring gene gag-pol fusion protein Neighboring gene gag protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae. Enjo F, et al. J Biol Chem, 1997 Aug 1. PMID 9235906
    2. Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) transporters. Ceschin J, et al. J Biol Chem, 2014 Jun 13. PMID 24778186, Free PMC Article
    3. Characterization of Thi9, a novel thiamine (Vitamin B1) transporter from Schizosaccharomyces pombe. Vogl C, et al. J Biol Chem, 2008 Mar 21. PMID 18201975
    4. Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters. Savocco J, et al. PLoS Biol, 2019 Oct. PMID 31658248, Free PMC Article
    5. Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy. Huang Z, et al. PLoS Genet, 2012. PMID 23209439, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters, Thi7, Nrt1, and Thi72.
      Title: Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables nucleobase transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleobase transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thiamine transporter
    NP_014835.3
    • Transporter of thiamine or related compound; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); shares sequence similarity with Thi7p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      698768..700567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183611.3 → NP_014835.3  TPA: thiamine transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014835.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2P8, Q08579
      UniProtKB/TrEMBL
      A6ZP37, B3LJM2, B5VS76, N1NWR2
      Conserved Domains (1) summary
      cd11482
      Location:27 → 505
      SLC-NCS1sbd_NRT1-like; nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08579.1

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