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    Tmem198b transmembrane protein 198b [ Mus musculus (house mouse) ]

    Gene ID: 73827, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tmem198bprovided by MGI
    Official Full Name
    transmembrane protein 198bprovided by MGI
    Primary source
    MGI:MGI:1921077
    See related
    Ensembl:ENSMUSG00000047090 AllianceGenome:MGI:1921077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110012D08Rik
    Summary
    Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to be active in cytoplasmic vesicle and plasma membrane. Orthologous to human TMEM198B (transmembrane protein 198B (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 11.6), limb E14.5 (RPKM 9.8) and 28 other tissues See more
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    Genomic context

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    See Tmem198b in Genome Data Viewer
    Location:
    10 D3; 10 77.16 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128633958..128641255, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128798089..128805386, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, alpha Neighboring gene STARR-positive B cell enhancer ABC_E10661 Neighboring gene STARR-seq mESC enhancer starr_28300 Neighboring gene predicted gene, 31504 Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene ribosomal protein SA, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E1817 Neighboring gene matrix metallopeptidase 19 Neighboring gene DnaJ heat shock protein family (Hsp40) member C14 Neighboring gene STARR-positive B cell enhancer ABC_E74 Neighboring gene ORM1-like 2 (S. cerevisiae) Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene STARR-positive B cell enhancer ABC_E10662

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC73827

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358266.1 → NP_001345195.1  uncharacterized protein LOC73827

      Status: VALIDATED

      Source sequence(s)
      AC131081
      Consensus CDS
      CCDS24293.1
      UniProtKB/TrEMBL
      Q8CFU0
      Conserved Domains (1) summary
      pfam13886
      Location:43 → 240
      DUF4203; Domain of unknown function (DUF4203)

    2. NM_001358267.1 → NP_001345196.1  uncharacterized protein LOC73827

      Status: VALIDATED

      Source sequence(s)
      AC131081
      Consensus CDS
      CCDS24293.1
      UniProtKB/TrEMBL
      Q8CFU0
      Conserved Domains (1) summary
      pfam13886
      Location:43 → 240
      DUF4203; Domain of unknown function (DUF4203)

    3. NM_178066.3 → NP_835167.1  uncharacterized protein LOC73827

      See identical proteins and their annotated locations for NP_835167.1

      Status: VALIDATED

      Source sequence(s)
      AC131081
      Consensus CDS
      CCDS24293.1
      UniProtKB/TrEMBL
      Q8CFU0
      Related
      ENSMUSP00000050451.8, ENSMUST00000051011.14
      Conserved Domains (1) summary
      pfam13886
      Location:43 → 240
      DUF4203; Domain of unknown function (DUF4203)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128633958..128641255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245325.1 → XP_030101185.1  uncharacterized protein LOC73827 isoform X2

      Conserved Domains (1) summary
      pfam13886
      Location:43 → 240
      DUF4203; Domain of unknown function (DUF4203)

    2. XM_030245324.1 → XP_030101184.1  uncharacterized protein LOC73827 isoform X2

      Conserved Domains (1) summary
      pfam13886
      Location:43 → 240
      DUF4203; Domain of unknown function (DUF4203)

    3. XM_006514226.5 → XP_006514289.1  uncharacterized protein LOC73827 isoform X2

      Conserved Domains (1) summary
      pfam13886
      Location:43 → 240
      DUF4203; Domain of unknown function (DUF4203)

    4. XM_006514224.5 → XP_006514287.1  uncharacterized protein LOC73827 isoform X1

      See identical proteins and their annotated locations for XP_006514287.1

      UniProtKB/TrEMBL
      Q8CFU0
      Conserved Domains (1) summary
      pfam13886
      Location:43 → 240
      DUF4203; Domain of unknown function (DUF4203)

    5. XM_030245321.1 → XP_030101181.1  uncharacterized protein LOC73827 isoform X1

      UniProtKB/TrEMBL
      Q8CFU0
      Conserved Domains (1) summary
      pfam13886
      Location:43 → 240
      DUF4203; Domain of unknown function (DUF4203)

    6. XM_006514225.5 → XP_006514288.1  uncharacterized protein LOC73827 isoform X1

      See identical proteins and their annotated locations for XP_006514288.1

      UniProtKB/TrEMBL
      Q8CFU0
      Conserved Domains (1) summary
      pfam13886
      Location:43 → 240
      DUF4203; Domain of unknown function (DUF4203)

    7. XM_030245322.2 → XP_030101182.1  uncharacterized protein LOC73827 isoform X1

      UniProtKB/TrEMBL
      Q8CFU0
      Conserved Domains (1) summary
      pfam13886
      Location:43 → 240
      DUF4203; Domain of unknown function (DUF4203)

    8. XM_006514222.4 → XP_006514285.1  uncharacterized protein LOC73827 isoform X1

      See identical proteins and their annotated locations for XP_006514285.1

      UniProtKB/TrEMBL
      Q8CFU0
      Conserved Domains (1) summary
      pfam13886
      Location:43 → 240
      DUF4203; Domain of unknown function (DUF4203)
    Nucleotide Protein Strain
    Heading Accession and Version

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