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    Ipo11 importin 11 [ Mus musculus (house mouse) ]

    Gene ID: 76582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ipo11provided by MGI
    Official Full Name
    importin 11provided by MGI
    Primary source
    MGI:MGI:2442377
    See related
    Ensembl:ENSMUSG00000042590 AllianceGenome:MGI:2442377
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ranbp11; 1700081H05Rik; 2510001A17Rik; E330021B14Rik
    Summary
    Enables nuclear import signal receptor activity. Acts upstream of or within ribosomal protein import into nucleus. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nuclear envelope. Is expressed in several structures, including early conceptus; germ cell of gonad; and islets of Langerhans. Orthologous to human IPO11 (importin 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.7), CNS E18 (RPKM 7.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ipo11 in Genome Data Viewer
    Location:
    13 D1- D2.1; 13 58.06 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (106930947..107073466, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (106794439..106936958, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35564 Neighboring gene predicted gene, 30411 Neighboring gene Ipo11-lrrc70 readthrough Neighboring gene predicted gene, 24527 Neighboring gene STARR-seq mESC enhancer starr_35565 Neighboring gene leucine rich repeat containing 70 Neighboring gene STARR-seq mESC enhancer starr_35568 Neighboring gene STARR-seq mESC enhancer starr_35569 Neighboring gene predicted gene, 57603 Neighboring gene STARR-seq mESC enhancer starr_35570 Neighboring gene STARR-positive B cell enhancer ABC_E1165 Neighboring gene DIM1 rRNA methyltransferase and ribosome maturation factor Neighboring gene kinesin family member 2A Neighboring gene STARR-positive B cell enhancer ABC_E7276 Neighboring gene RIKEN cDNA 3830408C21 gene Neighboring gene STARR-positive B cell enhancer ABC_E11558

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Importin-11 is Essential for Normal Embryonic Development in Mice. Lee JY, et al. Int J Med Sci, 2020. PMID 32218703, Free PMC Article
    2. The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. Chen M, et al. J Cell Biol, 2017 Mar 6. PMID 28193700, Free PMC Article
    3. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Gu Y, et al. Mol Cancer, 2021 Oct 14. PMID 34649567, Free PMC Article
    4. Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. Plafker SM, et al. Mol Cell Biol, 2002 Feb. PMID 11809816, Free PMC Article
    5. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.
      Title: Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (4) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough Ipo11-lrrc70

    Readthrough gene: Ipo11-lrrc70, Included gene: Lrrc70

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ribosomal protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    importin-11
    Names
    imp11
    ran-binding protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360897.1 → NP_001347826.1  importin-11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154328, BC031900
      Consensus CDS
      CCDS88519.1
      Related
      ENSMUSP00000140046.2, ENSMUST00000186033.7
      Conserved Domains (2) summary
      sd00044
      Location:426 → 459
      HEAT; HEAT repeat [structural motif]
      cl27876
      Location:10 → 981
      Cse1; Cse1

    2. NM_029665.4 → NP_083941.2  importin-11 isoform 1

      See identical proteins and their annotated locations for NP_083941.2

      Status: VALIDATED

      Source sequence(s)
      AC154328, AC165281
      Consensus CDS
      CCDS36776.1
      UniProtKB/Swiss-Prot
      Q8BU45, Q8K0B4, Q8K2V6
      Related
      ENSMUSP00000079667.8, ENSMUST00000080856.14
      Conserved Domains (3) summary
      COG5657
      Location:10 → 972
      CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
      pfam03810
      Location:28 → 100
      IBN_N; Importin-beta N-terminal domain
      sd00044
      Location:426 → 459
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      106930947..107073466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175202.2: Suppressed sequence

      Description
      NM_175202.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2V6.1 GenPept UniProtKB/Swiss-Prot:Q8K2V6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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