UBASH3B ubiquitin associated and SH3 domain containing B [Homo sapiens (human)] - Gene

Summary

Official Symbol: UBASH3Bprovided by HGNC
Official Full Name: ubiquitin associated and SH3 domain containing Bprovided by HGNC
Primary source: HGNC:HGNC:29884
See related: Ensembl:ENSG00000154127 MIM:609201; AllianceGenome:HGNC:29884
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p70; STS1; STS-1; TULA2; TULA-2
Summary: This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
Expression: Broad expression in spleen (RPKM 7.0), placenta (RPKM 6.8) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q24.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (122655722..122814473)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (122683359..122842181)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (122526430..122685181)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression.
Title: FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression.
Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCdelta protein.
Title: Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCδ protein.
An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling.
Title: An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling.
These studies help define a critical role of Ubash3b in leukemia
Title: Integrative phosphoproteome and interactome analysis of the role of Ubash3b in BCR-ABL signaling.
the UBASH3B gene rs4936742 (T > C) polymorphism is associated with an increased risk of Behcet's disease, especially non-ocular BD, in Iranian population. We could not find any susceptibility role of this genetic locus for posterior uveitis in Behcet's disease.
Title: Ubiquitin Associated and SH3 Domain Containing B (UBASH3B) Gene Association with Behcet's Disease in Iranian Population.
Sts-1 is a negative regulator.
Title: The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis.
UBASH3A/STS-2/TULA exhibits substantial homology to UBASH3B/STS-1/TULA-2, but possesses only a small fraction of phosphatase activity of UBASH3B/STS-1/TULA-2, and thus, its regulatory effect may be based also on the phosphatase-independent mechanisms. Critical physiologic effects of these proteins have been demonstrated in T lymphocytes, platelets, stem cells, and other important cell types.
Title: TULA-family proteins: Jacks of many trades and then some.
Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of ZAP70.
Title: Insights into the suppressor of T-cell receptor (TCR) signaling-1 (Sts-1)-mediated regulation of TCR signaling through the use of novel substrate-trapping Sts-1 phosphatase variants.
The results show that the interaction between STS-1 and ShcA is regulated in response to EGF receptor activation.
Title: Identification of STS-1 as a novel ShcA-binding protein.
The study reveals a role of CBL in restricting myeloid proliferation of human AML1-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention.
Title: UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids. EBI GWAS Catalog EBI GWAS CatalogPubMed
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S1336 (e-PCR), detects polymorphism
- UniSTS:71465

G09553 (e-PCR)
- UniSTS:77891

D11S3069 (e-PCR)
- UniSTS:152166

DXS8337 (e-PCR)
- UniSTS:64635

SHGC-54247 (e-PCR)
- UniSTS:2948

D11S1269 (e-PCR)
- UniSTS:148363

D11S2064 (e-PCR)
- UniSTS:31132

SHGC-148327 (e-PCR)
- UniSTS:176327

RH99018 (e-PCR)
- UniSTS:90066

D11S3556 (e-PCR)
- UniSTS:152795

D11S1336 (e-PCR), detects polymorphism
- UniSTS:85981

G59531 (e-PCR)
- UniSTS:136693

SHGC-153746 (e-PCR)
- UniSTS:177915

SHGC-153747 (e-PCR)
- UniSTS:177916

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of bone resorption	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of platelet aggregation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of osteoclast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin-associated and SH3 domain-containing protein B

Names: Cbl-interacting protein Sts-1; SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate; T-cell ubiquitin ligand 2; cbl-interacting protein p70; nm23-phosphorylated unknown substrate; suppressor of T-cell receptor signaling 1; tyrosine-protein phosphatase STS1/TULA2

NP_001350294.1

EC 3.1.3.48

NP_116262.2

EC 3.1.3.48

XP_005271769.1

EC 3.1.3.48

XP_011541343.1

EC 3.1.3.48

XP_054226245.1

EC 3.1.3.48

XP_054226246.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363365.2 → NP_001350294.1 ubiquitin-associated and SH3 domain-containing protein B isoform 2

Status: VALIDATED

Source sequence(s)

AP002762

Conserved Domains (2) summary

cd07067
Location:351 → 563

HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

cd11936
Location:221 → 282

SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
NM_032873.5 → NP_116262.2 ubiquitin-associated and SH3 domain-containing protein B isoform 1

See identical proteins and their annotated locations for NP_116262.2

Status: VALIDATED

Source sequence(s)

AK075203, AP002762, BC007541, CR741636

Consensus CDS

CCDS31694.1

UniProtKB/Swiss-Prot

Q53GT5, Q53GT8, Q8NBV7, Q8TF42, Q96IG9, Q96NZ2

Related

ENSP00000284273.5, ENST00000284273.6

Conserved Domains (3) summary

cd07067
Location:386 → 598

HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

cd11936
Location:256 → 317

SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B

cd14301
Location:39 → 76

UBA_UBS3B; UBA domain found in ubiquitin-associated and SH3 domain-containing protein B (UBS3B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

122655722..122814473

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005271712.4 → XP_005271769.1 ubiquitin-associated and SH3 domain-containing protein B isoform X1

Conserved Domains (3) summary

cd07067
Location:414 → 626

HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

cd11936
Location:284 → 345

SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B

cl21463
Location:83 → 104

UBA_like_SF; UBA domain-like superfamily
XM_011543041.3 → XP_011541343.1 ubiquitin-associated and SH3 domain-containing protein B isoform X2

Conserved Domains (2) summary

cd07067
Location:367 → 579

HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

cd11936
Location:237 → 298

SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

122683359..122842181

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054370270.1 → XP_054226245.1 ubiquitin-associated and SH3 domain-containing protein B isoform X1
XM_054370271.1 → XP_054226246.1 ubiquitin-associated and SH3 domain-containing protein B isoform X2