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    rrf-1 RNA-directed RNA polymerase [ Caenorhabditis elegans ]

    Gene ID: 172523, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rrf-1
    Official Full Name
    RNA-directed RNA polymerase
    Primary source
    WormBase:WBGene00004508
    Locus tag
    CELE_F26A3.8
    See related
    AllianceGenome:WB:WBGene00004508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DEAD/H-box RNA helicase binding activity and RNA-dependent RNA polymerase activity. Involved in siRNA processing. Located in mutator focus and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rrf-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    20
    Sequence:
    Chromosome: I; NC_003279.8 (7643431..7649777, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Lipid droplet-associated hydrolase Neighboring gene Nuclear cap-binding protein subunit 2 Neighboring gene RNA-directed RNA polymerase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Silencing of host genes directed by virus-derived short interfering RNAs in Caenorhabditis elegans. Guo X, et al. J Virol, 2012 Nov. PMID 22896621, Free PMC Article
    2. An atypical RNA quadruplex marks RNAs as vectors for gene silencing. Roschdi S, et al. Nat Struct Mol Biol, 2022 Nov. PMID 36352138, Free PMC Article
    3. Expression of Caenorhabditis elegans RNA-directed RNA polymerase in transgenic Drosophila melanogaster does not affect morphological development. Duan G, et al. Transgenic Res, 2010 Dec. PMID 20140643
    4. Gene silencing by double-stranded RNA from C. elegans neurons reveals functional mosaicism of RNA interference. Ravikumar S, et al. Nucleic Acids Res, 2019 Nov 4. PMID 31501873, Free PMC Article
    5. Antiviral RNA silencing initiated in the absence of RDE-4, a double-stranded RNA binding protein, in Caenorhabditis elegans. Guo X, et al. J Virol, 2013 Oct. PMID 23885080, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here we demonstrate that EGO-1 can compensate for the lack of RRF-1 when dsRNA from neurons is used to silence genes in intestinal cells.
      Title: Gene silencing by double-stranded RNA from C. elegans neurons reveals functional mosaicism of RNA interference.
    2. rrf-1 mutants display several phenotypes not previously appreciated, including broader tissue-specific RNAi-processing capabilities
      Title: C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline.
    3. Present evidence for successive engagement of two different RdRPs (RRF-3/RRF-1) in an endogenous siRNA-based mechanism targeting specific mRNAs in C. elegans soma.
      Title: Distinct phases of siRNA synthesis in an endogenous RNAi pathway in C. elegans soma.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DEAD/H-box RNA helicase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-dependent RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-dependent RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA-dependent RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-dependent RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleotidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mutator focus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear RNA-directed RNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-directed RNA polymerase
    NP_001250555.1
    • Confirmed by transcript evidence
    NP_001250556.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7643431..7649777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001263626.4 → NP_001250555.1  RNA-directed RNA polymerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250555.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECM1
      Conserved Domains (1) summary
      pfam05183
      Location:479 → 1035
      RdRP; RNA dependent RNA polymerase

    2. NM_001263627.3 → NP_001250556.1  RNA-directed RNA polymerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MU40
      Conserved Domains (1) summary
      pfam05183
      Location:398 → 954
      RdRP; RNA dependent RNA polymerase

    RNA

    1. NR_050268.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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